Presentations in GI Flashcards
GI causes of epigastric pain
Duodenal/gastric ulcers, oesophagitis, ruptured AAA
Non-GI causes of epigastric pain
Pericarditis, MI, ASC, diabetic ketoacidosis
Causes of central abdominal pain
Bowel obstruction, early appendicitis, acute gastritis, acute pancreatitis, ruptured AAA, ischaemic bowel disease
GI causes of left upper quadrant pain
Splenic rupture, splenic artery aneurysm, sub-phrenic abscess, pathology from epigastric region - ulcer, acute pancreatitis, oesophagitis
Non-GI causes of left upper quadrant pain
Pneumonia, ACS, diabetic ketoacidosis
Differentials of left upper quadrant mass
Splenomegaly, Gi malignancy, ectopic kidney, transplanted kidney, incisional hernia, sebaceous cyst, lipoma
Normal pathopysiology of bilirubin
Bilirubin is the breakdown product of RBCs, it is a yellow/orange bile pigment which is excreted in urine or faeces.
What are the normal levels of bilirubin and urobilinogen present in urine
Bilirubin is absent, urobilinogen present
In disease what are the levels of bilirubin
Prehepatic absent, hepatic present, posthepatic present
In disease what are the levels of urobilinogen
Prehepatic increased, hepatic increased, posthepatic decreased or absent
What happens in pre hepatic jaundice
Results in unconjugated hyperbilirubinaemia, which is not water soluble so does not enter urine
Causes of post hepatic jaundice
PBS, PSC, gall stones, head of pancreas adenocarcinoma, cholangiocarcinoma, biliary atresia, some drugs such as steroids, sulfonylureas, nitrofurantoin, flucloxacillin, co-amoxiclav
Causes of post hepatic jaundice
Conjugation disorders - Gilberts, Crigler-Naajjar. Haemolysis - malaria or haemolytic anaemia. Drugs - contrasts or rifampicin
What happens in hepatic jaundice
Hepatocellular dysfunction resulting in conjugated hyperbilrubinaemia
Causes of hepatic jaundice
Viruses (Hep, CMV), alcohol, cirrhosis, abscess, malignancy, AIAD, Wilson’s, haemochromatosis, Budd-Chiari, Drugs (paracetemol, valproate, statins, halothane, TB antibiotics)