prenylation Flashcards
1
Q
what can the prenyl group be
A
farnesyl c15
or
geranylgeranyl c20
2
Q
what form do the prenyl groups come in
A
farnesyl diphosphate
geranylgeranyl diphosphate
3
Q
groups transfered to what and where and by what
A
cysteine
at c terminal
by stable thioester bond
4
Q
where is the cysteine found
A
4th from c terminus
part of CaaX motif
a= aa
X c15 or 20
5
Q
what cleaves ther terminal tripeptide
A
prenyl-specific endopeptidase
6
Q
specific methyl transferase does what
A
methylates the carboxyl terminal of the cysteine
7
Q
farnesyl group will
A
reversibly bind protein to membrane
seen with ras family
acts as molecular switch
8
Q
perminant target is achieved by either
A
palmitoylation at the plasma M
or
electrostatic interactios of the cluster of cationic residues with anionic phospholipids
