Prenatal Heart Development

Question 1

1. cells form the embryonic mesoderm and ectoderm gradually differentiate into……

Answer 1

specific cardiac cell types

Question 2

2. differentiation of cardiac cells is driven by ___________ responding to…….

Answer 2

• transcription factors
• environmental signals from surrounding cells

Question 3

3. ____ ______- cells derived from the embryonic mesoderm migrate within the early embryo to form the _________ _____________ during gestational week _

Answer 3

• myocardial progenitor cells
• cardiac crescent
• 2

Question 4

4. from the cardiac crescent, the ___________ forms during the ___ week of gestation & and begins to ___ at ~22 days after conception

Answer 4

• primitive heart tube
• third
• beat

Question 5

5. myocardial progenitor cells differentiate into multiple cell types including (list 3)

Answer 5

• cardiomyocytes
• endothelial cells
• conductive cells

Question 6

5. as these cells differentiate, looping and folding produces the ______

Answer 6

heart chambers

Question 7

6. ectoderm-derived cardiac neural crest cells migrate towards and joint the heart by gestational week _ & differentiate into ________________ within the aorta and pulmonary arteries and neurons

Answer 7

• 4
• smooth muscle cellss