Prenatal Exposure to Drugs & Theories Flashcards
Addiction
-“Addiction is a primary, chronic disease of brain reward, motivation, memory, and related circuitry.”
Components of Addiction
- Inability to abstain
- Impaired behavioral control
- Craving
- Diminished recognition of problems resulting from addiction
- Dysfunctional Emotional Response
Family and Addiction
- Addiction of grandparents and other family members
- Lack of access to resources and support
- Low socio-economic status
- Domestic violence
- Abusive behavior (physical, emotional, sexual)
- Mental health issues in mother and other family members
How extensive is the addiction problem?
- 3 million 12 year olds and up used illicit drugs for the first time in 2010
- 8100 people a day used illicit drugs for the first time in 2010
- Average age of initiation was 19.1 years
- Finnegan scale is used to access infants who are prenatally exposed.
- Whatever age a person starts using drugs is their mental age.
Pregnancy and Illicit Drug Use 1
- 6% of pregnant women ages 15-44 reported non-medical use of prescription type psychotherapeutic drugs in the past year
- 4.5 % of pregnant women used illicit drugs the month before
- Types of drugs:
- 4.4% pain relievers
- 2% Tranquilizers
- 1.3% Stimulants
- 0.8 % Methamphetamines
- 0.3% Sedatives
- Infants are often exposed to more than 1 drug
- Some pregnant women will use opiates and anti-depressants
Pregnancy and Illicit Drug Use 2
- 4.4% of pregnant women reported current drug use:
- 22 % Crack/Cocaine
- 21% Methamphetamine
- 17% Marijuana
- Of the estimated 4.4% of pregnant women (ages 15-44), that continue to use illicit drugs:
- 16.2% 15-17 year olds
- 7.4% 18-25 year olds
- 1.9% 26-44 year olds
NAS-Neonatal abstinence syndrome
- “A generalized disorder characterized by central nervous system hyper-irritability, gastro-intestinal dysfunction, respiratory distress and vague autonomic symptoms.” (Finnegan & Weiner, 1993)
- Occurs due to exposure in-utero to either licit or illicit drugs of abuse or from postnatal iatrogenic effects
- Opiods (ex. Methadone, codeine, oxycodone, heroin) are the most common drugs from which infants withdraw
- Exposure to opiates can lead to NAS in 60-90% of infants (up to 60% require pharmacologic treatment)
- Opiod withdrawal is one of the few disorders that can be treated
- Different than prenatal exposure to drugs (all babies do not get addicted)
- Actually addicted to the drugs
- Neonatal withdrawal usually occurs in 48-72 hours, but in some cases it can take 2-4 weeks
- Most severe symptoms (tremors/sweating) can take 6 months-1 year
General Risks Associated with Prenatal Exposure to Drugs
- SIDS
- IUGR-intrauterine growth restriction
- Pre-term labor and delivery
- Learning disabilities
When to screen for NAS- Infant red flags
- Prematurity
- IUGR (unexplained)
- Neurobehavioral Abnormalities
- Atypical CVA’s
- Myocardial Infarctions
- NEC (Necrotizing enterocolitis)
- NEC-bowel needs to be resected
- preterm infants, less than 30 weeks have less chance of experiencing withdrawal because their CNS has not developed completely
When to screen for NAS- Mother red flags
- Lack of prenatal care
- Unexplained fetal demise
- Placental abruption
- Severe mood swings
- CVA’s
- Myocardial Infarctions
- Repeated spontaneous abortions
How do we test for NAS
- Urine Drug Screening- usually only shoes recent exposure
- Meconium Drug Screening- (most accurate)
- Umbilical Cord Toxicology Screening
- Hair Testing- detect drug use for several months
Do all infants with NAS look the same?
- Presentation differs based on 3 primary factors:
- Type (not amount) of drug abused
- Time between last use by mother and delivery
- Maternal / infant metabolism and excretion
- Other factors may impact how infant presents
- They don’t all look the same
The signs and symptoms of NAS
- Neurological Excitability- tremors, increased wakefulness, high pitched crying, exaggerated reflexes, a lot of sneezing and yawning, 2-11% opiate withdrawal have seizures
- Gastrointestinal Dysfunction-poor feeding, uncoordinated suck, vomiting, diarrhea, dehydration
- Autonomic Signs- sweating, nasal stuffiness, fever, modeling, temperature instability
Feeding the infant with NAS
- Poor Feeding
- Uncoordinated Suck
- Vomiting
- Diarrhea
- Dehydration
- Poor Weight Gain
Managing poor feeding in the infant with NAS
- Low lactose, soy, or elemental formula (helps will feeding intolerance and cramping)
- Mylicon (avoid use of sucrose)
- Manage environment
- Decrease extraneous noise
- Consistency
- Dim lighting
- Managing GERD
- Elevating head of bed
- Thickening feedings (though research doesn’t support use of thickened liquid as reliable for managing reflux)
- Increase frequency / reduce volume of feeding
Managing Poor Feeding in the Infant with NAS (Sucking)
- Uncoordinated sucking prevents infant from efficient intake
- Frustration increases due to inability to take in liquid efficiently
- Hyperactive gag – may be exacerbated by incoordination
- Swaddling may support organization
- External pacing may be required
- Temperature control may influence organization
Vomiting & Diarrhea in NAS
- Lead to dehydration/poor weight gain
- Increased caloric expenditure secondary to increased activity/agitation
- Increasing caloric density may promote weight gain (24-27 cal/oz)
- May use Immodium if diarrhea causes too much weight loss
- Clonidine
Breast Feeding the Infant with NAS
- Minimal amounts of methadone cross into the breast milk so the advantages outweigh the issues
- MBM is more easily tolerated
- Indirectly decreases symptoms of NAS
- By decreasing gastrointestinal irritation scores are lower (good)
- Improved gastrointestinal tolerance results in better growth
- Lowered NAS scores result in less dosage of meds needed to treat the infant for withdrawal
When not to breast feed with NAS
- If mother is taking:
—-Marijuana – fat soluble
—-Amphetamines- irritability, sleep problems
—-Cocaine- irritability, vomiting, seizures
—-Heroin- irritability
Pharmacologic Treatment of NAS
- Morphine (primary)
- Methadone (primary)
- Clonidine (secondary)
- Phenobarbital (secondary)
- babies are on a very rigid feeding schedule because of medication
Marijuana
- Dried material from hemp plant.
- Cannabis Sativa
- Passes rapidly into blood
- 8-9 tetrahydrocannabinol (THC) primary psychoactive component
- THC binds to cannabinoid receptors (CB1) and modifies the release of neurotransmitters
Fetal and Neonatal Effects of Marijuana
- THC easily crosses the placenta and is present in amniotic fluid
- High lipid solubility, slow elimination, prolonged fetal exposure
- Cannabinoid receptors present in early gestation which modifies neurotransmitters (serotonin, dopamine, GABA), altered neuronal growth, maturation and differentiation, and structural or functional abnormalities
- Impact generally subtle, outcomes usually associated with heavy or frequent use
Complications of Fetal Exposure to Marijuana
- Intrapartum
- Dysfunctional labor
- Meconium stained AF (amniotic fluid)- can happen in infants that are not exposed to drugs (indicates distress) - Neonatal
Prematurity
- Long Term
- Tremors (fine)
- Poor sleep
- Visual reasoning poor- reading
- Poor memory and verbal skills
- Abnormal attention
- Slightly increased risk for SIDS
Cocaine (4)
- Alkaloid extracted from leaves of Erythroxylon coca bush
- Forms:
- Coca paste- 80% coke
- Cocaine HCI- snorted or injected
- Alkaloidal base- freebasing
- Crack Cocaine- most popular form
Cocaine Pharmacology 1
- 3 neurotransmitters are affected:
- norepinephrine, dopamine, serotonin
- Inhibits reuptake of NE and D, accumulates at synapse, resulting in prolonged stimulation of receptors
- NE stimulation (tachycardia, HTN, diaphoresis (excessive sweating) , tremors
- Dopamine stimulation (increased alertness, euphoria, enhanced feeling of well-being, heightened energy
Cocaine Pharmacology 2
- Decreases reuptake of tryptophan affecting serotonin biosynthesis
- Decreased serotonin, decreased need for sleep
- —(sleep-wake cycle is disregulated)
- Low molecular weight, high lipid solubility, crosses placenta by simple diffusion
- Cocaine and metabolites are slow to be eliminated which increases toxicity to fetus
- Placental perfusion decreases- blood flow from mom to fetus decreases
- Congenital malformation not increased
Complications of Exposure to Cocaine 1
1. antebirth
- intrapartum
- Antenatal (before birth)
- Stillbirth
- Abortion
- Infection/STD
- Placental infarcts
- IUGR
- Abnormal fetal breathing - Intrapartum (during childbirth)
- Premature labor
- PROM- premature rupture of membranes
- Shortened labor
- Meconium stained amniotic fluid
Complications of exposure to cocaine 2
1. Neonatal
- Long term
- Neonatal
- PT, LBW, SGA (similar gestational age)
- Postnatal growth restriction
- Cerebral Infarction
- Seizures
- Cortical Atrophy
- IVH
- Abnormal EEG and BAER
- NEC
- Intestinal Perforation
- Low birth weight, very low birth weight, extremely low birth weight - Long Term
- Expressive/Receptive Language
- Delay/Disorder
- Poor Recognition/memory/info processing
- Decreased visual attention
- Behavioral issues (ADHD)
Amphetamines
- Methyphenyethlamine
- Metamphetamine
- Methyphenyethlamine – stimulant of norepinephrine, dopamine, and serotonin release
- Metamphetamine (meth, speed, ice, crystal)
- Higher CNS stimulation, less PNS and cardiovascular stimulation
Effects of Amphetamines
- Euphoria
- Aggressive Behavior
- Arrhythmias
- Anxiety
- Seizures
- Shock
- Stroke
- Abdominal Cramps
- Insomnia
- Death
Complications of Amphetamines
- Antenatal
- fetal death
- Retroplacental hemorrhage - Neonatal
- Prematurity
- Neonatal Death
- Drug Intoxication
- Tremors
- Abnormal Sleep Cycle- no sleep for 3 days really affects the baby
- Poor Feeding
- Hypertonia
- Sneezing
- High-pitched cry
- Loose stools
- Fever
- Yawning
- Hyperreflexia
Long-Term Complications of Amphetamines/Methamphetamines
- Decreased IQ
- Aggressive behavior
- Peer-related problems
- Poor academic performance
Tobacco
-Approximately 20% of women smoke during pregnancy
- Nicotine is a primary psychoactive chemical with the following fetal effects:
- baby is usually very small
-Use of tobacco during pregnancy results in complications for the infant
Complications of Fetal Tobacco Exposure
- Fetal
- Intrapartum
- Neonatal
- Fetal
- SAB- spontaneous abortion
- Stillbirth
- Placental decidual necrosis - Intrapartum
- Abruption
- Premature labor - Neonatal
- IUGR
- CHD- congestive heart disease
- Deformities of extremities, polycystic kidneys***, gastroschisis (born with their intestines on the outside) , skull deformities
- PPHN- persistent pulmonary hypertension
Long-term complications of tobacco
- Low test scores (cognitive, language, general academic achievement)
- Behavior disorder
- Adolescent onset of drug dependence
- SIDS
Teratogenic Effects of Alcohol
- Direct toxic effect on cells
- Hypoxia (secondary to impaired placental / fetal blood flow)
- Cell migration in the brain is effected
- Apoptosis is effected
- Weaning off of morphine usually takes 3-4 weeks
- Neurobehavioral assessment may be done by an SLP or OT
- Follow up is very important
- NAS is not FAS
Characteristics of Fetal Alcohol Syndrome 1
- Symptoms range from mild to severe
- Abnormal facial features
- Smooth philtrum
- Small head size
- Shorter than average height
- Low body weight
- Poor coordination
Characteristics of Fetal Alcohol Syndrome 2
- Hyperactive behavior
- Problems with the heart, kidneys, and bones
- Difficulty paying attention
- Poor memory
- Difficulty in school (math especially)
- Learning disabilities
Characteristics of Fetal Alcohol Syndrome 3
- Speech and language delays
- Intellectual disability or low IQ
- Poor reasoning and judgment
- Sleep problems as baby
- Sucking problems as baby
- Vision and hearing issues
Theory
Hypothesis to abstract concept (not definite end)
Model
Experiment to concrete outcome
Descriptive-Developmental Model
- Based on Neurodevelopment Framework Theory of Language
- Components
—-Higher Order Cognition
—-Attention
—-Memory
—-Social Cognition
—-Neuromotor Position
—-Language
—-Temporal sequential ordering
***Praxis info
Foundations and background of Descriptive developmental model
- Ex. If a student is struggling with attention in class, the problem would be assessed via a neurodevelopment profile (through observation)
- Behavior and work
- Patterns and themes
- Strengths, weaknesses, and affinities
- Specify where learning is breaking down, but you are not labeling the child
Affliation
- The neurodevelopmental framework which is the foundation for the Descriptive-Developmental Model aligns itself with the Specific Disabilities Model (individuals with a LD differ in their ability)
- Use child’s strengths to work on weaknesses
Founders of Neurodevelopmental Framework Theory
- Dr. Mel Levine founded the Neurodevelopmental Framework Theory
-Graduated from Brown University,
Rhodes Scholar at Oxford, Graduated From Harvard Medical School, Completed Pediatric Training at Children’s Hospital in Boston,
Chief of Division of Ambulatory Pediatrics (14 years), Became associate professor at Harvard Medical School
-Served as a Professor of Pediatrics at UNC
School of Medicine
- Co-founder of Success in Mind
- Every child is unique (not just lumped into a diagnosis or condition)
- Avoid lumping into categories
- Avoid potentially stigmatizing labels
Transition- Neurodevelopment Framework Theory led to
- Neurodevelopment Framework Theory led to the Descriptive-Developmental Model
- Descriptive-Developmental Model founded by Dr. Lois Bloom and Dr. Margaret Lahey
Dr. Lois Bloom
- BA from Penn State
- Masters from University of Maryland
- Doctorate from Columbia (Psychology & Education)
- Began her professional career as SLP
- Founder of Descriptive-Development Model
Dr. Margaret Lahey
- BS from State University of New York at Geneseo
- Masters from Ohio State University
- Doctorate from Columbia (Education)
- Began her professional career as SLP
- Founder of Descriptive-Development Model
Basics of the descriptive development model
- Descriptive – Perform analysis and provide a detailed description of the child’s language
- Developmental – Determine child’s level of functioning, where that fits in the normal developmental sequence, provides information for what should come next
- Treating each individual area of language is key