Pregnancy termination small animal

Question 1

Pregnancy maintenance depends on what throughout pregnancy?

Answer 1

CL

Question 2

What is the corpus luteum dependent on in the dog?

Answer 2

luteinizing hormone

prolactin

Question 3

Why are estrogens used in mismating historically?

Answer 3

alter ova transit time
interfere with implantation
effective at cetain stages of estrous cycle
oral or injectible

Question 4

What are the toxic (dose-related) effects of estrogens?

Answer 4

1. thrombocytopenia
2. anemia
3. leucopenia
4. pancytopenia
5. cystic endometrial hyperplasia-pyometra

Question 5

Is dexamethasone used for preg termination?

Answer 5

yes but not often

used midgestation

Question 6

What is mifepristone?

Answer 6

a progesterone antagonist that MAY work in dogs–not yet used

Question 7

What is aglepristone?

Answer 7

progesterone antagonist
may work in midgestation
used in europe, maybe could get through emergency drug release

Question 8

What are progesterones used for?

Answer 8

termination of pregnancy
as is luteolytic and myotonic. can be used as early as day 6 of diestrus
side effects are common
PGF2alpha analogues also available

Question 9

What are the effects of prostaglandins on the preg uterus?

Answer 9

1. increase motility and tone
2. dilation of cervix
   ==>expulsion of uterine contents

Question 10

What are the side effects of prostaglandins?

Answer 10

1. hyperpnea
2. hypersalivation
3. vomition
4. defecation
5. hypothermia

Question 11

What are bormocriptine and cabergoline?

Answer 11

prolactin inhibitors
vomiting is a side effect
prevents mammary enlargement
slow in evacuation of uterine contents
(may be added with prostaglandin)

Question 12

Are there ideal aboritfacients in the dog?

Answer 12

no, many drugs have secere side effects and/or need to be given at specific times
expulsion of dead or alive fetuses