Pregnancy Pharmacology Flashcards

1
Q

What do Uterotonic Drugs do?

A

Stimulate Uterine contraction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What do Tococlytic Drugs do?

A

Inhibit Uterine Contractions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What drugs can be used to induce labor?

A

Oxytocin, Misoprostol, Dinoprostone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What drugs can be used for Cervical Ripening?

A

Misoprostol and Dinoprostone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What drugs can be used for post-partum to aid in placental delivery

A

Oxytocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What drugs can be used for bleeding control post-partum

A

Oxytocin, Misoprostol, Carboprost, Methylergonovine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What Calcium Channel blocker can be used for short-term control of premature labor?

A

Nifedipine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How does Insulin help in gestation diabetes?

A

Insulin stimulates Glucose transporter expression and uptake of plasma glucose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Do Glipizide and Glyburide (2nd gen sulfonylureas) cross the placental barrier?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What drugs are used for Gestational HTN?

A

Methyldopa, Labetalol, and Nifedipine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What HTN Drug is only used for HTN emergencies in pregnancy?

A

Hydralazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What drug is given in severe pre-eclampsia to prevent seizures?

A

Magneisum Sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What drug is an Alpha 1, Beta 1, and Beta 2 antagonist?

A

Labetalol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is special about Methyldopa?

A

Methyldopa is an Alpha-2 agonist.

Alpha 2 is a pre-synaptic receptor that inhibits the release of NE from the neuron. Results in decreased sympathetic output.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of Hydralazine

A

Directly inhibits vascular smooth muscle contraction by blocking IP3-induced release of Calcium ions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mifepristone MOA for Safe abortion

A

Mifepristone is a progesterone antagonist that disrups the endometrium preventing implantation

17
Q

MOA of Methotrexate as an abortifacients

A

Methotrexate is a Dihydrofolate reductase (DHFR) inhibitor that blocks tetrahydrofolate (THF) synthesis and DNA replication.

18
Q

Indomethacin MOA

A

Indomethacin is a COX1 inhibitor that decreases prostaglandin production and reduces uterine smooth muscle contraction

19
Q

_ and _ are tocolytic drugs that act by agonizing B2 receptors

A

Terbutaline and Ritodrine are tocolytic drugs that act by agonizing B2 receptors
* Recall that albuterol is also a b2 agonist that relaxes smooth muscle in the bronchioles

20
Q

(Terbutaline/ Ritodrine) has serious fetal and maternal health risks meaning its use is limited

A

Terbutaline has serious fetal and maternal health risks meaning its use is limited

21
Q

The insulin receptor is a _ type receptor that autophosphorylates and increases the expression of GLUT4 transporters

A

The insulin receptor is a tyrosine kinase receptor that autophosphorylates and increases the expression of GLUT4 transporters
* Insulin does not cross the placenta

22
Q

Metformin (does/does not) cross the placenta

A

Metformin does cross the placenta but it is still safe for the fetus

23
Q

Metformin MOA

A

Inhibits gluconeogenesis