Embryology Flashcards
What are the main events during Weeks 1-2 of fetal development
Fertilization
Implantation in endometrium of uterus
Formation of two layers
Development of primitive streak
What are the main events during Weeks 3-8 (Embryonic Period) of fetal development
Formation of three layers
Beginning of development of all organs and body parts (Organogenesis)
What are the main events during weeks 9-38 (Fetal Period) of fetal development
Growth and maturation of organs and body parts
One cell divides and gives
rise to two genetically
identical daughter cells,
each with the same 46
chromosomes as the
mother cell
Mitosis
____ only occurs in the germ
cells and gametes are
formed through this
process, which results in
four genetically different
haploid cells ensuring
genetic diversity.
Meiosis
Spermatogenesis Diagram
Oogenesis Diagram
What is the most likely location of abnormal implantation?
Ampulla of the fallopian tube
The egg is released from where before it enters the fallopian tube?
Ovarian Follicle
What propels the ova down the fallopian tube toward the uterus?
The movement of cilia
Process in which a sperm combines with an ovum to produce a zygote
Fertilization
What is the glycoprotein later; defense against multiple sperm penetration
Zona Pellucida
biochemical change in outer layer of sperm that allows it to be successfully fertilized in the egg
Sperm Capacitation
After Fertilization, a _ develops on day 4, a _ on day 5, and the Blastocyst implants on day _
After Fertilization, a **Morula develops on day 4, a *Blastocyst on day 5, and the Blastocyst implants on day *6-10
The _ is the dorsal layer of the Bilaminar disc and forms the _
The Epiblast is the dorsal layer of the Bilaminar disc and forms the Entire Embryo
The _ is the ventral layer of the Bilaminar disc and forms the _
The Hypoblast is the ventral layer of the Bilaminar disc and forms the yolk sac lining
During which prenatal period would exposure to a
teratogenic drug, such as the antiepileptic
phenytoin, have the most profound effect on
development?
Weeks 3-8
When does Gastrulation occur and what occurs?
Week 3
Bilaminar disc trnasforms into a tilaminar disc
Organogenesis
What are the three layers in the Trilaminar disc?
Ectoderm
Mesoderm
Endoderm
What are the Surface Ectoderm Derivatives
- Epidermis and epidermal appendages
- Mammary Glands
- Adenohypophysis
- Parotid Gland
- Olfactory Epithelium
- Sensory organs of the inner ear
- Lens of the eye
- Anal canal below Pectinate Line
- Ameloblasts and tooth enamel
What are some Neuroectoderm Derivatives?
- Brain and Spinal Cord
- Somatic Motor Nerves
- Preganglionic Autonomic Nerves
- Neuroglia
- Neurohypophysis
- Retina
What are some Neural Crest Derivatives?
- Somatic Sensory Nerves
- Somatic and Autonomic Ganglia
- Postganglionic Autonomic Nerves
- Schwan Cells and Satellite Cells
- Pia Mater and Arachnoid Mater
- Adrenal Medulla
- Melanocytes of Skin
- Some head and neck connective tissue, dermism and bones
- Aorticopulmonary Septum
- Odontoblasts and Dentin
_ is composed of epiblast cells that migrate up and sandwiched between overlying ectoderm and underlying endoderm
Mesoderm is composed of epiblast cells that migrate up and sandwiched between overlying ectoderm and underlying endoderm
The _ forms muscle, blood cells, most connective tissue, dermis, cartilage, bone, and notochord
The mesoderm forms muscle, blood cells, most connective tissue, dermis, cartilage, bone, and notochord
Mesoderm defects can be remembered as
VACTERL
Vertebral defects
Anal atresia
Cardiac defects
Tracheo-Esophageal fistula
Renal defects
Limb defects
A premature infant has trouble breathing. The
clinician has found that the lining of the infant’s
alveoli does not produce enough surfactant to
allow for normal breathing. Which of the following
structures is derived from the same germ layer as
the respiratory lining cells that produce surfactant?
A. Epithelial lining of the stomach
B. Melanocytes
C. Retina
D. Spinal cord
E. Sternum
A. Epithelial lining of the stomach
_ is composed of epiblast cells that migrate and completely displace the hypoblast
Endoderm is composed of epiblast cells that migrate and completely displace the hypoblast
What linings, glands, and structures are formed by the endoderm?
What occurs during the Embryonic Period?
Organs and body parts continue to develop; Near complettion of the exterior body and early stages of all organ systems
Folding occurs during week 4, what does that look like?
The cranial end folds ventrally, the caudal end folds ventrally, and the lateral sides fold ventrally -> 3D trunk -> Limb buds
Gastrointestinal, respiratory, genitourinary, and cardiovascular system start to develop; heart starts to beat
What occurs during the Fetal Period
Organs and body parts continue to develop -> Near completion of theexterior body and early stages of all organ systems
What are four iimportant genes of Embryogenesis
- Sonic Hedghog (SHH)
- Wnt-7
- Fibroblast Growth Factor
- Homeobox (Hox)
Sonic Hedgehog gene location and function
Location: Zone of polarizing activity at base of limb buds
Function: Anterior-posterior axis patterning, CNS development
Wnt-7 Gene location and Function
Location: Apical ectodermal ridge at the distal end of end limb
Function: Dosral-ventral axis patterning limb development
Fibroblast growth factor gene location and function
Location: Apical ectodermal ridge
Function: Limb lengthening (via mitosis of mesoderm)
Homeobox gene location and function
Location: Multiple places
Function: Segmental organization in cranial-caudal direction, transcription factor coding
What do Transcription factors do in embryogenesis
Regulate which genes are activated or repressed
What does intracellular communcation do during embryogenesis
Interaction of a cell with a neighbor cell