pregnancy Flashcards

1
Q

Any female/partner of a male who uses Ribavirin requires what

A
  • two types of contraception
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2
Q

drugs have the most effects on which trimester

A
  • first trimester
    • but some effects occur later
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3
Q

as a rule of thumb, which of these two is more likely to cross the placenta: lipid soluable drug or highly ionized drug

A
  • lipid soluble drug
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4
Q

DOC for HTN in pregnancy

A

methyldopa

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5
Q

if a pregnant women is hypothyroid, give

A
  • levothyroxine
    • avoid cretinism
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6
Q

function of folic acid in pregnancy

A
  • prevent neural tube defects
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7
Q

define teratogen

A
  • agent that causes birth defect or congenital malformation
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8
Q

teratogenic exposure

A
  • teratogenic potential at clincal doses used in humans
  • teratogenic effect is not 100%
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9
Q

what is the category:

  • no fetal risk, possibility of fetal harm remote
A

category A

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10
Q

what is the category:

  • no risk animal, unknown human, probably okay
A

Category B

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11
Q

what is the category:

  • no adequate human or animal studies. use only if benefit outweight risk
A

Category C

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12
Q

what is the category:

  • evidence of fetal risk has been demonstrated. used only in life threatening disease or where other drugs carry a greater risk
A

category D

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13
Q

what is the category:

  • evidence of fetal damage. risk outweight any benefits
  • absolutely contraindicated
A

category x

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14
Q

clinical presentation

  • small head
  • simply formed, low set ears
  • thin upper lip
  • small chin
  • smaller eye opening
  • flat midface
  • short, upturned nose
A

fetal alcohol syndrome

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15
Q

clinical presentation

  • saddle nose
  • broad, short hands
  • opthalmic
  • bone
  • fetal death common
A

warfarin use in pregnancy

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16
Q

what should be used in pregnancy instead of warfarin for anticoagulant

A
  • heparin
    • doesn’t cross placenta
17
Q

thalidomide was used in pregnancy to

A
  • sedative
  • antinausea
18
Q

thalidomide caused what in babies

A
  • limb deformities
19
Q

phenytoin caused what in babies of pregnant women used

A
  • fetal hydantoin syndrome
    • growth retardation
    • cardiac abnormality
    • no finger or toe nails
    • abnormal genitalia
    • broad nose, cleft palate
20
Q

babies of pregnant women who used Diethylstilbestrol developed

A

vaginal adenocarcinoma

21
Q

What is the VACTERL symptoms?

A
  • vertebral: hypoplastic
  • anal problems
  • cardiac defect
  • trachea - esophageal fistulas
  • renal: poor development
  • limbs: lower arm, thumb
22
Q

VACTERL symptoms are associated with use of what in pregnancy

A

sex hormone use

23
Q

Isotretinoin MOA and use

A
  • binds to retinoic acid receptors and decreases sebaceous gland production
  • acne
24
Q

how many doses of Isotretinoin teratogenic

A
  • one dose is teratogenic
  • reqires iPLEDGE program
25
Q

can statins be used in pregnancy

A

CONTRAINDICATED

26
Q

List the drugs contraindicated in pregnancy

A
  • statins
  • warfarin
  • ergots
  • Flurazepam, temazepam
  • leflunomide
  • ethanol
  • misoprostol
  • thalidomide
  • methotrexate
  • sex hormones: mifepristone, raloxifene, finasteride
  • ribavirin
  • isotretinoin