NSAIDs II Flashcards
1
Q
differentiate between COX 1 and COX 2
A
- COX 2:
- inducible
- promotes inflammation
- inhibits platelet aggregation (PGI2)
- vasodilation (PGI2)
- COX 1
- inhibits gastric acid secretion -> protects against gastric irritation
- promotes platelet aggregation (TXA2)
- Vasoconstriction
2
Q
MOA of Celecoxib
A
- selective, reversible COX-2 inhibitors
- less risk of GI bleeding
3
Q
adverse reactions with Celecoxib
A
- increased risk of cardiovascular diseases
- platelet aggregation and constriction via unopposed COX-1
4
Q
contraindications to Celecoxib
A
- h/o heart problems
5
Q
MOA of Ibuprofen (Motrin)
A
- nonspecific reversible inhibitors of COX-1 and COX-2
- first choice drug
6
Q
toxicities of Ibuprofen
A
- overall toxicity is low. It is better tolerated than aspirin
7
Q
MOA of Indomethacin
A
- Nonspecific COX inhibitor
- inhibit phospholipase A (needed for arachidonic acid synthesis)
8
Q
use of Indomethacin
A
used for patent ductus arteriosus, gout
9
Q
MOA of Diclofenac
A
- potent nonspecific COX inhibitor
10
Q
Diclofenac is often combined with what to decrease GI side effects
A
Misoprostol
- combined name: arthrotec
11
Q
Use of Ketorolac (toradol)
A
- Nonspecific COX inhibitor used mostly as an analgesic in postsurgical pain
- may be combined with opiates
- can’t use for more than 5 days -> GI ulcer
12
Q
effect of patient taking ibuprofen while on long term ASA for anticoagulation
A
combination decreases the effect on platelet aggregation!
13
Q
MOA of Naproxen
A
- Nonspecific COX inhibitor
14
Q
unique about naproxen
A
- long half life!
- mean plasma half-life = 13 hours
15
Q
MOA of Piroxicam (Feldene)
A
- Nonspecific COX inhibitors
- inhibits PMN migration, lymphocyte function
- decreases oxygen radical production
