GI drugs II Flashcards
1
Q
MOA of the “Setron”s such as Ondansetron (Zofran)
A
- 5HT3 antagonists
2
Q
Use of Ondansetron (Zofran)
A
- nausea and vomiting induced by chemotherapy, radiation, gastric diseases
- NOT for motion sickness
3
Q
MOA of Prochlorperazine
A
- block DA, muscarinic, and histamine receptors
4
Q
MOA of Promethazine
A
- block DA, muscarinic, and histamine receptors
5
Q
use for Promethazine and Prochlorperazine
A
- highly sedating, post-op antinausea
- will work for motion sickness, not DOC
6
Q
MOA and use of of Dronabinol
A
- cannabinoid
- used for chemo-induced N/V
- stimulates appetite
7
Q
List the 5 types of laxatives
A
- bulk-forming: mild
- osmotic: intense
- mucosal agents: irritant
- lubricating agents
- stool softeners
8
Q
Explain the bulk forming laxative
A
- high fiber
- take with plenty of water
- bloating and flatulence common
9
Q
List the bulk forming laxatives
A
- Psyllium (Metamucil®)
10
Q
List the types of osmotic laxatives
A
- Magnesium hydroxide
- Sodium salts: oral or enema
11
Q
MOA of Polyethylene glycol
A
- laxative
- insoluble, holds water in intestine
12
Q
Use of Polyethylene glycol
A
- prep for colonoscopy: large volume consumed
- Miralax: OTC for occasional constipation, use for up to 7 days
13
Q
MOA and Use of Lactulose
A
- used in cirrhosis and liver disease to decrease blood ammonia levels
- anion trap of NH3 when it enters the GI lumen and converts it to NH4 (becomes trapped)
- causes diarrhea
14
Q
MOA of mucosal agents
A
- stimulate peristalsis
- enhance secretion/inhibit absorption H20
15
Q
List the mild mucosal agent
A
Senna (Senokot®)
