Pregnancy Flashcards
… and … are considered to be among the most important environmental factors influencing the course and outcome of pregnancy?
Maternal diet and nutritional status
How long is gestation and trimesters?
Gestation 40 weeks Divided into trimesters First trimester: 0-12 weeks Second trimester: 13-27 weeks Third trimester: 28-40 weeks
What happens at 0-2 weeks of fetal development?
fertilisation to embryonic disc, less sensitive to teratogenesis ( process by which congenital (disease from birth) malformations are produced) and high rate of lethality (death of embryo).
What happens to a foetus at 3-8 weeks?
Turns from embryo into fetus, most sensitive to teratogenesis, major organs form each of which have a peak sensitivity period.
What happens to a fetus from week 9 to 38?
Turns from fetus to baby, decreasing sensitivity to teratogenesis, period of growth and functional maturation.
Physiological changes during pregnancy?
Maternal weight gain and body composition changes
Blood volume expansion and cardiovascular changes
Renal changes
Respiratory changes
Gastrointestinal changes
Metabolic adaptations
Components of maternal weight gain during pregnancy?
Foetus (only a third of the weight gain, placenta and amniotic fluid
Mammary glands, uterus
Lean body mass, fat
Plasma volume, extracellular body water
Optimal maternal weight gain?
Underweight (< 18.5kg/m2) = 12.5 – 18kg Healthy (18.5 – 24.9kg/m2) = 11.5 – 16kg Overweight (25 – 29.9kg/m2) = 7 – 11.5kg Obese (>30kg/m2) = 6.8kg minimum No one should loose weight
Gastrointestinal Changes?
Adaptations to increase gut absorptive capacity influenced by progesterone and oestrogen
Increased availability to maternal and foetal structures and stores
Reduction in secretion of gastric juices
Gastric emptying slowed (food churned in stomach longer)
Motility of small and large intestine reduced (so food exposed to more enzymes)
The nutrient requirements during pregnancy must provide adequate nutrients to meet…?
The needs of the mother
The needs of the foetus
To some extent, then needs of mother and foetus in the future (lactation)
Maintenance of a normal pregnancy requires energy due to…?
increased mass of the uterus formation of the foetus formation of the placenta the expanded blood volume extra adipose tissue to provide energy reserve for lactation
Energy requirements may increase but what factors might slightly mitigate this effect/ cause issues?
BMR may decrease due to endocrine changes in pregnant women
Physical activity may decrease in the pregnant woman
Food intake may decrease in the pregnant woman
When does energy intake increase in pregnancy?
Last few weeks, average increase under 100 extra calories a day.
What are the recommendations for energy intake in the third trimester? Exceptions
Increase EAR by 200kcals/day above pre-pregnant EAR (only during last trimester)
Large increase in food intake NOT required
Maternal obesity associated with increased risk of congenital malformations
Exceptions:
women underweight at beginning of pregnancy, and women who do not reduce activity may need more
What is a better indicator than the recommendations of energy sufficiency?
Appropriate weight gain and appetite are better indicators of energy sufficiency that the amount of kcal consumed
Protein Requirements
Protein required for growth of the foetus and maternal tissue
Overall gain of almost 1kg protein during pregnancy
most during 1st to 2nd trimester
Increased protein turnover during pregnancy
Excess protein associated with health risks
DRV additional 6g /day (RNI 51g/day)
Current UK intakes in excess of RNI
After 20 weeks foetal liver can synthesise non-essential amino acids from precursors
Importance of lipids in pregnancy?
Crucial for foetal development
membranes and brain
Uptake depends on dietary supply
Effects
Depletion of DHA associated with reduced visual function and learning defects in children, supplementation from 2nd trimester may improved visual aspects and tests on intelligence and achievement in infants.
High intakes of n-3 fatty acids proposed to extend gestation, increase birth weight and reduce risk of premature delivery. Caution with increased intake from potential contamination of fish oils with mercury and other potentially teratogenic agents. Fish oil supplementation may increase maternal bleeding and risk of postpartum haemorrhage.
Importance of vitamin A and food recomendations?
Vitamin A
Required for growth and maintenance of foetus
Maternal requirements increased by 100µg throughout pregnancy but most UK women already consume sufficient
> 8000 µg/d increased risk birth defect
Advise
no liver/ liver products
No Vitamin A supplements
Vitamin C recommendation in third trimester?
Increase mothers RNI by 10mg/d
Vitamin D recommendations?
Vitamin D deficiency can be passed on to the baby during pregnancy
Requirement 10µg/d supplementary Vitamin D
If mother supplements with vitamins what should she take?
Avoid use of single vitamin supplementations
If supplementation necessary, use pregnancy suitable multi-vitamins (exclude vit. A)