Prac 11: Musculoskeletal

Question 1

What are the 2 types of cell that make up the synovial membrane?

Answer 1

Macrophage-like “Type A” synoviocytes and fibroblast-like “Type B” synoviocytes.

Question 2

Does the synovial membrane contain blood and lymphatics?

Answer 2

Yes, in abundance.

Question 3

Describe the relationship between GAGs, hyaluronic acid and proteoglycans

Answer 3

Hyaluronic acid has side-chains of proteoglycans (such as aggrecan) which have their own side chains of glycosaminoglycans (such as chondroitin sulphate).

Question 4

What are the two components contained within a Haversian canal?

Answer 4

Capillaries and connective tissue.

Question 5

From which cells are chondrocytes derived?

Answer 5

Osteoprogenitor cells

Question 6

Is there a significant increase in inflammatory cells in bone and soft tissue in osteoarthritis?

Answer 6

No

Question 7

What are the changes to the synovium in RA (4)?

Answer 7

Villous hyperplasia, mononuclear infiltrate, plasma cells, germinal centres

Question 8

What protein is the amyloid protein that can be deposited in RA derived from?

Answer 8

Serum amyloid associated protein (SAA protein)

Question 9

What are 4 conditions other than RA that can result in the same kind of amyloid being deposited?

Answer 9

Tuberculosis, inflammatory bowel disease, bronchiectasis, chronic osteomyelitis.