PPT Flashcards
NSAIDs effect on the kidney?
= they cause vasoconstriction of the afferent arteriole > reducing GFR
ACEi-i + ARBs effect on the kidney?
= they cause vasodilation of the efferent arteriole > reducing GFR (protective)
Which drugs should be stopped in AKI
(DAMN)
D - diuretics
A - ACEi + ARBs
M - Metformin
N - NSAIDs
Main side-effect of Propylthiouracil
- severe liver damage
When is Propylthiouracil use reserved for?
- pregnancy
- thyroid storm
Carbimazole Regimes: What is titration therapy?
= start high-dose and gradually reduce
Carbimazole Regimes: What is block + replace?
= high dose Carbimazole, then add Levothyroxine
Can you use block + replace Carbimazole regime in pregnancy?
= no, risk of neonatal hypothyroidism
In which situations might you not use radioactive iodine?
- pregnancy
- those with thyroid ophthalmopathy (makes it worse)
Effect of dopamine on prolactin
= inhibits
Pharmacological treatment for GAD
= SSRIs (Sertraline)
Benzodiazepines MOA
= facilitating the binding of the inhibitory neurotransmitter GABA at various GABA receptors throughout the CNS
What is Naltrexone, and what is it used for?
= opioid antagonist, used in detoxified + motivated patients tackling opioid misuse
What is Bupropion?
= nicotinic antagonist + noradrenaline + dopamine reuptake inhibitor (also antidepressant)
Which of the following best describes the effects of an opioid overdose (e.g., morphine, codeine, heroin etc.)
- reduced HR, RR, cold temp, pinpoint pupils, no bowel sounds
- raised HR, RR, fever, dilated pupils, loud bowel sounds + sweating
- reduced HR, RR, cold temp, pinpoint pupils, no bowel sounds
