poxviridae Flashcards
poxcviridae phylogeny
1) you get pox
2) skin lesions
3) viriola major and mino
- major: more severe, mortality is 1-3/10
poxviridae
1) 100 microns
2) almost like a bacteria
- dual membrane on outside
- vary large genome
- has own DNA replication enzymes
structure and lifecycle of
1) glycosaminoglycans cover all over the cell
2) broad tropism
3) 2 versions in the cell
pathogenesis
1) virus entry
2) blood circulation
3) liver spleen
4) very serious disease
5) can be released from the lesions
vaccination
1) cowpox virus
- vaccinia
2) the virus is the first vaccine
3) young women did not contract smallpox due to exposure of milking cows by hand
- gathered exudate from lesions o cow and innocutated other idividuals
4) they developed cowpox, but not small pox- live attenuated virus
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