papillomaviridae

Question 1

structure

Answer 1

1) overlaps in genome
2) individual pieces can come out of open reading frame
3) episomal

Question 2

lifecycle

Answer 2

1) verrucous lesions
2) papilloma infect basa lamina
2) accelerates the cell cycle
4) replication becomes rapid
5 thickening of epidermal tissue
- verrucae

Question 3

histology

Answer 3

1) most are benign
2) 16 ad 18 are associated with neoplastic changes
3) excisional biopsy
4) widespread lesions mya indicate an immunocompromised
5) referral for medical evaluation

Question 4

malignant transformation

Answer 4

1) e6 and e7 proteins play a role in neoplastic changes by inhibiting p53 and pRb
2) cell cycle disrupted and accelerated
3) red halo
- high chance of neoplastic changes
- may have penetrated basal lamina and immune system recognized it