adenoviridae

Question 1

adenoviruses phylogeny

Answer 1

1) infect human and nonhuman
2) discovered in adenoid tissue
3) broad tropism
- infect different types of tissue
4) do not have a membrane when budding
- gets out of the cell like lysis

Question 2

adenoviridae structure

Answer 2

1) small virus
2) protein nobs
3) outer protein coat
4) inside is viral genome with accessory proteins
5) does not need okazaki fragments, it can go both ways smoothly

Question 3

how does adenoviridae get in

Answer 3

1) docks at cell surface receptors
2) causing cell signaling and changes in cell skeleton
3) membrane folds in and endocytoses the virus

Question 4

open reading frame

Answer 4

1) transcribed region of genome
2) might code for multiple overlapping proteins
3) multiple start points in it

Question 5

adenovirus cell cycle

Answer 5

1) docking and endosome
2) endosomal acidification
- allows docking mechanisms and virus to separate
3) allows virus to move to nucleus for replication
4) builds proteins for progeny

Question 6

pathogensesis

Answer 6

1) inflammatory milieu
2) global signaling that promotes immune activation
- inflammation due to cytokines and interleukins

Question 7

clinical manifestations

Answer 7

1) upper respiratory infection
2) treatment
- we do not treat it directly

Question 8

genetic therapies

Answer 8

1) adenovirus can deliver healthy genes
- ex. covid 19 vaccine, cystic fibrosis