Powerpoint 11: Cronobacter Flashcards
How was it originally described?
pigmented yellow coliform
Where is it the most diagnosed?
Developed world - probably due to underdiagnosis in the developing world
What is the fatality range?
40-80%
What does it cause?
severe neurological disorders
1- necrotizing enterocolitis
2-septicemia
3-meningitis
What foods can harbor it?
milk powder, cheese, herb, rice, spices
What is the role of outer membrane proteins?
- contribution to export of virulence factors
- anchoring the structures that allow adherence and motility
What is the role of outer membrane protein a ? ompA
helps cells adhere to the GI tract
What is necessary for the cronobacter to have to reach the blood brain barrier?
needs ompA
What is the role of outer membrane protein X? ompX
- invasion on the apical side of the GI tract
- survive on the basolateral side
What is special about the pESA3 plasmid?
encodes an outer membrane protease
Where is the pESA3 plasmid found?
C. sazakii
What is the role of the outer membrane protease found on the pESA plasmid?
1) serum resistance:
- cleaves complement components
- activates plasminogen
- inactivates a plasmin inhibitor
2) type 6 secretion system
3) adhesin factors
What is the gene found in C. sazakii that allows for sialic acid utilization?
nanAKT cluster
What is the maximum amount of hang time allowed for milk prepared?
never exceed 4 hours
How many species of cronobacter exist?
11 species
