P0werP0int 9: Campyl0bacter

Question 1

What is thought to export virulence factors?

Answer 1

flagellar export

Question 2

What is an example of an exported virulence factor?

Answer 2

CiaB (strains without it are less virulent)

Question 3

What is common to patients with blood in their stools?

Answer 3

plasmid pVir

Question 4

What is encoded in the plasmid pVir?

Answer 4

Type 4 SS

Question 5

What is the toxin called?

Answer 5

Cytolethal Distending Toxin (CDT)

Question 6

What are the components of CDT?

Answer 6

Coded by cdtA, cdtB, and cdtC

Question 7

Which 2 components of the CDT toxin bind to the cell membrane ?

Answer 7

CdtA and Cdt C

-allow entry of Cdt B

Question 8

What does the CdtB do?

Answer 8

Enters the nucleus, causes DNA damage, leads to disruption of mitosis and cell death

Question 9

What causes the diarrhea?

Answer 9

CdtB kills the cells of the epithelium, leading to permeability

Question 10

Where is it most found?

Answer 10

water and chicken

Question 11

The outbreak was due to people eating what?

Answer 11

• chicken liver

- also from handling pets

Question 12

Where is it found?

Answer 12

Canada, US, all of the world

Question 13

What can it cause?

Answer 13

• bacteremia: immunocompromised individuals ; associated with c.jejuni. C.coli, c.fetus
• brain abscess: c. fetus
• esophageal disease (GERD / barret esophagus): c.cnscicous
• Inflammatory bowl disease
• periodontis
• paralysis: Guillam barr syndrome (GBS) or fisher miller syndrome (MFS) ; by c.jejuni; cross reaction of antibodies with peripheral nerve surface gangliosides