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Microbiology Semester 3 > Power Points From Whatsapp > Flashcards

Power Points From Whatsapp Flashcards

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Biology 101 flashcards
1
Q

Genus features of mycobacteria

A

Acid fast rods with waxy cell wall

Obligate aerobe

Sensitive to UV

Cell wall

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2
Q

What are the features of the mycobacterium cell wall?

A

High lipid concentration, mycolic acids

Resistance to desiccation and chemicals

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3
Q

What species of mycobacterium are medically important

A

Tuberculosis
Leprae
Avium intracellulare
Kansasii
Marinum
Ulcerans

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4
Q

Mycobacterium tuberculosis feature that is staining Fluorescent apple green

A

Auramine rhodamine staining bacilli

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5
Q

Tuberculosis is positive for

A

Acid fast bacilli

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6
Q

Tuberculosis is aerobic and slow growing an

A

Löwenstein-Jensen medium

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7
Q

Tuberculosis produces

A

Niacin

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8
Q

What type of catalyse does tuberculosis produce

A

Heat sensitive (active at body temperature)

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9
Q

Where is the reservoir of tuberculosis

A

Lungs

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10
Q

Transmission of tuberculosis is through

A

Respiratory droplets

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11
Q

Tuberculosis is a — intracellular organism

A

Facultative

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12
Q

Tuberculosis has sulfolipids in cell envelope that inhibit

A

Phagosome - lysosome fusion

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13
Q

What are the effects of cord factor of tuberculosis

A

Causes serpentine growth
Inhibits leukocyte migration which disrupts mitochondrial respiration

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14
Q

Tuberculosis has a surface protein called tuberculin with mycolic acid, this causes

A

Delayed hypersensitivity and cell mediated immunity

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15
Q

What are the symptoms of primary pulmonary tuberculosis

A

Fever and dry cough

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16
Q

Where do the tuberculosis replicate killing them until cell mediated immunity is reached

A

Naive alveolar macrophages

17
Q

What is a ghon complex

A

Lesson seen in the lesion by tuberculosis

18
Q

What do the macrophages do in tuberculosis

A

Transport bacilli to regional lymph node

19
Q

Symptoms of reactivation TB

A

Fever, hemoptysis, night sweats. weight loss

20
Q

Erosion of granulates into airways from TB later in life under conditions of reduced + cell immunity can lead to

A

Mycobacterium replication and disease symptoms

21
Q

Reactivational TB is complex with potential of

A

Infecting any organ systems

22
Q

reactivational TB may disseminate

A

Kidney, GI tract, brain, spine

23
Q

What is pott disease

A

Dangerous musculoskeletal tuberculosis

Bone destruction, deformity and paraplegia

24
Q

In the diagnosis of TB, microscopy of sputum is done what is it screened with

A

Auramine rhodamine stain (florecent green apple)

25
Q

mycobacteria is Acid fast, ham will it appear in UV

A

Yellow or orange

26
Q

How is PPD skin test done for TB

A

purified protein derivative tuberculin is injected into inner forearm skin surface

27
Q

Positive ppd test looks like

A

Swollen reddish skin ranging from 5-15mm

28
Q

What does quantiferon TB gold test measure

A

Interferon- gamma production when leukocytes are exposed to TB antigens

29
Q

TB is slow growing on which medium

A

Löwenstein-Jensen

30
Q

TB produces _ and is negative for -

A

Niacin
Does not produce catalyse

31
Q

What is the treatment for standard observed short- term therapy for uncomplicated pulmonary TB in the first 2 months

A

Ripe

Rifampin
Isoniazid
Pyrazinamide
Ethambutol

32
Q

The last 4 months of uncomplicated pulmonary TB ore treated with

A

Rifampin
Isoniazid

33
Q

What is added to TB treatment in the case of possible drug resistance

A

Streptomycin

34
Q

What 3-5 previously unused drugs can be administered for multi-drug resistant TB

A

Aminoglycosides
Fluroquinolones
Thioamine
Cycloserine
Bedaquiline

35
Q

What can be done to prevent TB

A

BCG vaccine
Isoniazid for nine months(infection with no symptoms)
UV or hepa filter

36
Q

Non TB mycobacteria are non contagious, where can they be found

A

Surface water
Soil
cigarettes

Microbiology Semester 3 (7 decks)

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