Potpurri Flashcards

1
Q

How does Fibroblast growth factor (FGFR3) work?

A

causes inhibition of condrocyte proliferation
destroys normal process of bone formation over a cartilage based ossifcatin center leading to a decrease in longitiudinal bone growth

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2
Q

Symmetric IUGR causes
Asymmetric IUGR casues

A

Symmetric : Intrauterine infection and chromosomal abnormalities

Asymmetric: Preeclampsia

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3
Q

Maternal transfer of estrogen through the placenta can lead to ?

A

cervical ectropion, and bilateral galactorrhea

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4
Q

Which of the following fingers are most likely to be joined by syndactyly in this condition?

A

index and middle finger

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5
Q

How can cause hyperglycemia cause birth defects?

A

increase oxidative stress and DNA damage
high glucose can lead to inhibition of PAX2 gene, which increases neural tube defects

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6
Q

What causes head tilted to ipsilateral side, chin to opposite side

A

head tilted to ipsilateral side, chin to opposite side
(due to unilateral contractures of sternocleidomastoid)

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7
Q

What is MYCN?

A

a proto-oncogene can be seen in Neuroblastoma, increased activity means worse prognosis

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8
Q

what is clubfoot deformity?

A

Clubfoot deformity includes cavus of the midfoot, adduction of the forefoot, varus of the hindfoot, and equinus

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9
Q

What do dark lung fields suggest on CXR

A

poor pulmonary blood flow

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10
Q

What is most common malignancy of infancy

A

neuroblastoma
(monitor with ultrasound, may regress)
and surgical resection if grows

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11
Q

Umbilical arterial blood gas values that are always true of umbilical artery compared to umbilical vein

A

umbilical artery has lower ph, higher PCO2, lower PO2
UA will always be worse than UV
uteroplacental insufficiency, both values bad

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12
Q

Microdeletion or uniparental disomy most common cause of Prader wili?

A

Microdeletion, about 70% of cases

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13
Q

What is SMART objective in learning

A

Specific, measurable, attainable, relevant and targeted to learner

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14
Q

pyramid of educational outcome measures

A

knows (knowledge), competence (knows how), performance (shows how) action (does)

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15
Q

Galacitol

A

the unusual accumlation that causes symptoms of galactomsemia
(galactose 1 phosphate accumulation, leads to too much Galacitol)
leading to eye findings (cataracts)

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16
Q

Line of demarcation ROP

A

represents stage I ROP, first stage

17
Q

Data Type Nominal

A

Order and magnitude of number not important
gender, race

18
Q

Data Type Ordinal

A

Order is important, not magnitude
grading of severity, IVH, ROP

19
Q

Data Type Ranked

A

order my magnitude, then assigned number rank
(leading causes of death)

20
Q

Data Type Discrete

A

Integer or Counts
number of kids, deaths, accidents

21
Q

Data Type Continuous

A

Measurable quantities, fractional values possible

22
Q
A

mode, median, mode

23
Q

What is Power In Statstics

A

1- Type II error rate

24
Q

What are advantages of case control study

A

you can study rare outcomes

25
Q

What portion of umbilical artery remains patent after birth? What does it supply?

A

Becomes superior vesical artery, supplies the bladder

26
Q

When do you treat nasolacrimal duct obstruction with topical abx?

A

fever, irrritiablity, mild edeam and erythema and distention of lacrimal sac below the medial canthal tendon.

27
Q

Name several factors that could present at birth of growth restricted infants

A

RDS, MAS, hypoglycemia, polycythemia, sepsis, thermoregulation, sepsis, non-physiologic hyperbili, hypocalcemia

28
Q

how long before baby exposed to alcohol begins to withdraw?

A

3- 12 hours

29
Q

How do diabetes and hypothyroidism affect bilirubin clearance?

A

causes decreased bilirubin clearance

30
Q

Donor breast milk what happens to triglycerides and free fatty acids

A

Triglycerides decreased, but free fatty acids increased

31
Q

What can inhibit fetal lung production?

A

Epinephrine and beta adrenergic agonists

32
Q

What happens before birth with ENAC channels?

A

respiratory epithelium changes from chloride secreting membrane to a sodium absorbing membrane.

33
Q

High glucose levels do what to PAX 3 gene?

A

inhibits PAX 3, which can lead to neural tube defects

34
Q

Lamellar bodies and Tubalr myelin like catipellar and butterfly.
How?

A

Lamellar bodies are released into air spaces by endocytosis, and then unravel in airspace, tubular myelin then formed under influence of calcium in SPA -SPAB