Potpurri Flashcards
How does Fibroblast growth factor (FGFR3) work?
causes inhibition of condrocyte proliferation
destroys normal process of bone formation over a cartilage based ossifcatin center leading to a decrease in longitiudinal bone growth
Symmetric IUGR causes
Asymmetric IUGR casues
Symmetric : Intrauterine infection and chromosomal abnormalities
Asymmetric: Preeclampsia
Maternal transfer of estrogen through the placenta can lead to ?
cervical ectropion, and bilateral galactorrhea
Which of the following fingers are most likely to be joined by syndactyly in this condition?
index and middle finger
How can cause hyperglycemia cause birth defects?
increase oxidative stress and DNA damage
high glucose can lead to inhibition of PAX2 gene, which increases neural tube defects
What causes head tilted to ipsilateral side, chin to opposite side
head tilted to ipsilateral side, chin to opposite side
(due to unilateral contractures of sternocleidomastoid)
What is MYCN?
a proto-oncogene can be seen in Neuroblastoma, increased activity means worse prognosis
what is clubfoot deformity?
Clubfoot deformity includes cavus of the midfoot, adduction of the forefoot, varus of the hindfoot, and equinus
What do dark lung fields suggest on CXR
poor pulmonary blood flow
What is most common malignancy of infancy
neuroblastoma
(monitor with ultrasound, may regress)
and surgical resection if grows
Umbilical arterial blood gas values that are always true of umbilical artery compared to umbilical vein
umbilical artery has lower ph, higher PCO2, lower PO2
UA will always be worse than UV
uteroplacental insufficiency, both values bad
Microdeletion or uniparental disomy most common cause of Prader wili?
Microdeletion, about 70% of cases
What is SMART objective in learning
Specific, measurable, attainable, relevant and targeted to learner
pyramid of educational outcome measures
knows (knowledge), competence (knows how), performance (shows how) action (does)
Galacitol
the unusual accumlation that causes symptoms of galactomsemia
(galactose 1 phosphate accumulation, leads to too much Galacitol)
leading to eye findings (cataracts)