MFM Flashcards
what can phenobarbital cause in pregnancy?
can cause neonatal abstinence syndrome. Newborns may develop poor feeding, high-pitched crying, diarrhea, hyperacusis, irritability, tremors, restlessness, hyperreflexia, and hypertonia.
congenital heart defects, craniofacial abnormalties, facial clefts.
What type of antibodies cross the placenta?
IgG
What happens to maternal blood pressure during pregnancy?
Decreases
at lowest point in 2nd trimester
What happens to hormones PTH and TSH in pregnancy?
PTH increases
T4 increases, TSH decreases (pregnant woman remain euthyroid)
What does human placental lactogen do?
increases lipid utilization, and has anti-insulin affect.
What crosses placenta via pinocytosis?
IgG 2nd trimester, some proteins
What crosses placenta via active transport?
amino acids, Calcium, Mag, Phos, iron iodine
What crosses placenta via facilitated diffusion?
glucose, keflex
what are some issues with velamentous cord insertion?
increase risk of intolerance to labor with some causes, due to lack of Wharton’s Jelly, vessels can be compressed during contraction
(umbilical cords inserts into chorio-amniotic membranes outside placental margin, and vessels travel within membrane of placenta)
What are issues with vasa previa?(fetal)
occurs with velamentous insertion of cord many times, membranes cross internal os and present prior to fetal head
Myasanthea Gravis can lead to what in neonate if antibodies directed to fetal Ach receptor?
fetal arthrogryposis
What electrolyte abnormality in infant do you see in Maternal diabetes?
hypocalcemia
(decreased placental transfer, PTH production, hypomagnesimia, decreased CA absorption in intestine)
What defects might you see with elevated AFP?
Open neural tube defects
What defects might you see with lower AFP
Trisomies
What are components of quad screen?
AFP, unconjugated Estriol, maternal B-hcg, inhibin A