Potassium Sparing Diuretics

Question 1

Types of PS Diuretics

Answer 1

• Sodium Channel Blocker: Amiloride, Triamterene.
• Aldosterone Antagonist: **Spironolactone, Eplerenone **(Act on late distal tubule and collecting tubule)

Question 2

Mechanism of Action

Answer 2

Spironolactone and Eplerenone binds to aldosterone receptorss, blocking the action of aldesterone. Aldesterone causes sodium and water retention and pottasium excretion

Traimterene and Amiloride do not block the aldosterone receptors but instead directly interere with Na+ entry via ion channels

Question 3

Adverse Effects

Answer 3

Hyperkalemia

Question 4

Therapeutic Use

Answer 4

• prevent K+ depletion in aldoseronism
• primary hyperaldosteronism (Conn’s Syndrome)
• Hypokalemia

Question 5

Drug Interactions

Answer 5

• Triamterene and Spironolactone can be inhibited by NSAIDs.
• Oral Potassium administration should be discontinued if Potassium-sparing Diuretics is being administered