Loop Diuretics

Question 1

Types of LDs

Answer 1

• Furosemide (Lasix)
• Bumetaanide (Bumex)
• Ethacrinic Acid (Edeerin)
• Torsemide (Demadex)

Question 2

MOA

Answer 2

• Inhibit Na+/ K+/ 2CL- co-trasn system in ALH
• Reduce reabsorption of NaCL
• Causes increase in magnesium, calcium & potassium excretion
• Descending Loop permeable to water

Question 3

Adverse Effects

Answer 3

• Hypokalemia
• Hyperuricemia
• Hypomagnesium
• Severe dehydration
• Hyponatremia
• Hypocalcemia
• Allergic reactions (rash, eosinophilia, nephritis)

Question 4

Therapeutic Use

Answer 4

• Acute pulminary edema
• hypercalcemia
• hyperkalemia
• Acute renal failure
• Cognitive Heart failure
• Hypertension