post op pain Flashcards
what can make acute pain worse
anxiety
increased sympathetic output
poor rest
inadequate oral intake
opioids and non opioids modulate pain..
peripherally and centrally
serious side effects of NSAIDS
GI toxicity
decreased renal function
absolute contraindications to NSAIDs
allergy
pregnancy
erosive or ulcerative conditions of the GI mucosa
relative contraindications to NSAIDs
asthma
anticoagulant therapy or hemorrhagic disorders
compromised renal function
COX-2 selective NSAIDs action
anti inflammatory, anty pyretic, analgesic
protect normal physiologic processes
why dont we just use COX-2 inhibitors only
poor efficacy in third molars
expensive
only one option
increased embolic phenomena
SULFA ALLERGY
how does acetaminophen work
probably blocks PG synthesis in CNS
does acetaminophen have anti inflammatory effects n
no
recommended daily maximum for tylenol
FDA: 4000 mg/day
McNeil Consumer: 3000 mg/day
daily maximum of tylenol for ppl with liver disease
2000 mg/day
which opioid receptors are more potent as far as analgesia, resp depression, sedation
mu > kappa
rank from most potent to least: hydro, oxygen, codeine
oxy > hydro > codeine
how do tylenol and semi synthetic opiate receptors work together
synergistically
reduces Amt of opioid needed, tylenol dictates dose/frequence
what converts oral opiates to active metabolites
cyp450
codeine active metabolite
morphine (effect entirely from metabolite)
hydrocodone active metabolite
hydromorphone (effect from parent drug and metabolite)
oxycodone active metabolite
oxymorphone (effect almost entirely from parent drug)
how many caucasians are deficient in cyp450
4-10%
pentazocine MOA
oral agonist-antagonist
analgesic at kappa, antagonist at mu
is pentazocine good for third molars
no
tramadol MOA
central dual action:
weak binding at mu
inhibit incoming nociceptive impulses