diabetes Flashcards
how many americans have diabetes
30 million
how many americans dont know they have diabetes
1 in 4
how many americans are pre diabetic
1 in 3 (90% dont know)
prediabetes fasting glucose level
between 100-125 mg/dL
pre diabetes glucose level after 75 g oral glucose challenge
140-199 mg/dL
pre diabetes HbA1C
5.7-6.4
assume that _____% of patients may display baseline dsyglycemia
more than 30%
what can surgery do to pre diabetics
hyperglycemia (stress)
diabetics have problems metabolizing….
carbs
proteins
lipids
how does glucose enter a cell
insulin binds to alpha chains on cell membrane
beta chains are phosphorylated
intracellular tyrosine kinase activated
insulin receptor substrates are activated
synthesis of various substances including glucose transport protein
glucose transport protein binds to cell membrane, glucose can enter now
normal blood sugar
75-100
when normal glucose transport is inhibited, blood glucose levels…..
rise
full blown diabetes HbA1c
more than 6.5
controlled diabetes HbA1c
less than 7
how many DM2 patients have no comorbidities
only 14%
most common comorbities DM2 (5)
obesity
CV dz
HTN
dyslipidemia
kidney dz
most common cause of mortality in diabetic pts
cardiovascular dz
what CV condition is poorly tolerated by diabetic pts
tachycardia
10x increase risk of death if HR more than 105 for 5 min in post op period