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IMMUNE1 LAB PRELIMS > POST LAB EXP 4 and 5 > Flashcards

POST LAB EXP 4 and 5 Flashcards

1
Q

adherence

A

PHYSICAL CONTACT

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2
Q

– squeezing of blood vessel walls; non-directional

A

Diapedesis

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3
Q

– directional

A

Chemotaxis

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4
Q

– associated with groups of pathogens; Innate immune system

A

Pathogen Associated Molecular Patterns (PAMPS)

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5
Q
  • recognize and adhere to pathogens
A

Pattern Recognition Receptors (PRRS)

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6
Q

blood and lymph

A

Secreted PRRs

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7
Q

circulating that binds to PAMPs

A

Secreted PRRs

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8
Q

triggers the complement cascade leading to opsonization

A

Secreted PRRs

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9
Q

Binds to pathogen leading to release of effector molecules (cytokines)

A

Phagocytosis Receptors

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10
Q

recognize PAMPs with mannose

A

Phagocytosis Receptors

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11
Q

set of transmembrane receptors

A

Toll-like Receptors

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12
Q

Toll-like Receptors found in:

A

MACs, DCs, epithelial cells

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13
Q

fruitfly Drosophilia: antifungal

A

Toll-like Receptors

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14
Q

Toll-like Receptors inc conc:

A

monocytes, MACs, neutrophils

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15
Q

ingestion

A

FORMATION OF PHAGOSOME

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16
Q

phagosome + lysosome = PHAGOLYSOSOME

A

FUSION OF PHAGOLYSOS OME

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17
Q

respiratory burst

A

DIGESTION

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18
Q

failed phagocytosis (innate/1st line of defense)

A

PHAGOCYTIC
CAPABILITY

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19
Q

20 –

A

lymph nodes (bacteremia), thymus

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20
Q

10 –

A

bone marrow; spleen

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21
Q

Automated system for identifying cells based on light scattering

A

CELL FLOW CYTOMETRY

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22
Q

Segmented lymphocytes; labelled Abs

A

FLOW CYTOMETRY

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23
Q

Chronic granulomatous disease and Leukocyte adhesion deficiency

A

FLOW CYTOMETRY

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24
Q

NITROBLUE TETRAZOLIUM TEST
: reagent

A

NBT

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25
Q

Deep blue

A

NITROBLUE TETRAZOLIUM TEST

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26
Q

Colorless WBC - CGD

A

NITROBLUE TETRAZOLIUM TEST

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27
Q

CHEMICAL NATURE

A
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28
Q

excellent antigens

A

Proteins

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29
Q

High MW and structural complexity

A

Proteins

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30
Q

Less immunogenic than protein

A

Polysaccharides/Carbohydrates

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31
Q

Relatively smaller

A

Polysaccharides/Carbohydrates

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32
Q

considered too small to function as antigens

A

Polysaccharides/Carbohydrates

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33
Q

B cells do not recognize

A

Polysaccharides/Carbohydrates

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34
Q

Antigenic if linked w/ proteins

A

Lipids

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35
Q

Inferior Ag

A

Lipids

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36
Q

Relative simplicity

A

Lipids

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37
Q

Lack of structural stability

A

Lipids

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38
Q

Poor antigens

A

Nucleic acids

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39
Q

Relative simplicity, molecular flexibility, and rapid degradation

A

Nucleic acids

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40
Q

Easily degradable

A

Nucleic acids

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41
Q

– degree to which antigenic determinants are recognized as non-self by an individual’s immune system

A

Foreignness

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42
Q

↑ foreign

A

↑ immunogenic

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43
Q

↓ degradable

A

↑ immunogenic

44
Q

For an antigen to be recognized as foreign by an individual’s immune system, sufficient antigens to stimulate an immune response must be present

A

DEGRADABILITY

45
Q

↑ MW

A

↑ immunogenic

46
Q

the better the molecule will function as an antigen.

A

The higher the MW,

47
Q

The number of antigenic determinants on a molecule is directly related to its size.

A

MOLECULAR WEIGHT

48
Q

↑ stable

A

↑ immunogenic

49
Q

If a molecule is an effective antigen (?) is mandatory

A

structural stability

50
Q

(e.g., gelatin),the molecule will be a poor antigen

A

structural stability

51
Q

the greater is its effectiveness

A

COMPLEXITY

52
Q

substance that stimulates antibody formation

A

Antigens

53
Q

Antigens ex

A

protein, lipids, polysaccharides, nucleic acids

54
Q

macromolecules capable of triggering an adaptive immune response by inducing the formation of antibodies or sensitized T cells in an immunocompetent host\

A

Immunogens

55
Q

Immunogens ex

A

protein, large polysaccharides

56
Q

Antigenic but not immunogenic

A

Hapten

57
Q

a low-molecular-weight, nonantigenic substance that, when combined with an antigen, changes the antigenic specificity of that antigen

A

Hapten

58
Q

a. According to relation to host

A
59
Q

b. According to how the antigens are found in the body

A
60
Q

c. According to their ability to stimulate immune response

A
61
Q

d. According to serologic behavior

A
62
Q

– same individual

A

Autologous

63
Q

– identical – of the host

A

Syngeneic

64
Q

–same species

A

Allogeneic/homologous/isoantigen

65
Q

– animals

A

Xenogeneic

66
Q

– unrelated plants and animals

A

Heterophile

67
Q

cross-reacts with Abs

A

Heterophile

68
Q

– different species giving the same response

A

Heteroantigen/Heterogeneic

69
Q
  • hidden antigens; not capable of inducing self-tolerance
A

Sequestered

70
Q

– characteristic of one tissue/cell; associated with autoimmunity

A

Tissue-specific

71
Q

– MHC/HLA

A

Tissue type

72
Q

– ABO, Rh

A

Blood group

73
Q
  • protein; indirect stimulation
A

T-dependent

74
Q
  • polysaccharide; direct stimulation
A

T-independent

75
Q

– able to elicit T-cell responses by circumventing normal Ag processing and presentation functions

A

Super antigens

76
Q

ability to bind to invariant region of Class II

A

Super antigens

77
Q

B- chain of the B cell Ag receptor

A

Super antigens

78
Q

with 3 constant domains

A

IgG. IgA, IgE

79
Q

pentamer

A

IgM

80
Q

complement fixation

A

IgG. IgM

81
Q

secretons

A

IgA

82
Q

a. According to relation to the host

A
83
Q

b. According to production in immune response

A
84
Q

c. According to serologic behaviour

A
85
Q

d. According to temperature reaction

A
86
Q

– react with many RBCs

A

Polyagglutinin

87
Q

– react against all reagent cells in an Ab panel rather specific cells

A

Panagglutinin

88
Q

– formed after exposure to environmental agents

A

Naturally-occurring

89
Q

– sensitization (transfusion, pregnancy)

A

Immune

90
Q

– streptolysin O and S

A

Hemolysin

91
Q

Warm reacting –

A

IgG

92
Q

Cold reacting –

A

IgM

93
Q

e. According to biologic fixation

A
94
Q

f. According to clonal production

A
95
Q

– against viral surface Ags

A

Neutralizing antibody

96
Q

– mast cells/basophils and eosinophils

A

Allergic/reaginic antibody

97
Q

heavy chain

A

a. Isotypes

98
Q

constant chain

A

b. Idiotypes

99
Q

variable regions

A

c. Allotypes

100
Q

main Ab directed

A

a. Classical

101
Q

with Ab

A

b. Alternate

c. Mannose-binding lectin

102
Q

early defense

A

b. Alternate

103
Q

Excess Ab; Serum dilution

A

Prozone

104
Q

Excess Ag; Repeat test

A

Postzone

105
Q

has the ability to bind to an antibody or a T lymphocytes antigen receptor

A

Antigens

106
Q

may not be able to evoke an immune response initially (e.g., haptens)

A

Antigens

IMMUNE1 LAB PRELIMS (9 decks)

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