PORTEC 4a

Question 1

Study question PORTEC 4a?

Answer 1

Using molecular profile to determine if adjuvant therapy (obs, VBT or EBRT) vs standard VBT

Question 2

PORTEC 4a hypothesis

Answer 2

Risk profiles similar survival info on molecular, so may spare adjuvant treatment

Question 3

PORTEC 4a study design

Answer 3

Ph 3 RCT 2:1 (molecular adjusted tx or VBT); vaginal recurrence (1’); pelvic and distant recurrence, OS, QoL and HC costs

Question 4

Inclusion criteria PORTEC 4a?

Answer 4

HIR EECa s/p hyst/BSO; Stage 1A, G3; Stage 1B G1 or 2 with 60y +/- LVI; Stage 1B G3; Stage 2 G1 microscopic