GOG99, 2004

Question 1

What is the study question for GOG99?

Answer 1

1987-1995; pelvic RT in Stage 1 endometrial ca (indications) - people w/ ECa were received post op RT despite low risk recurrence

Question 2

Remember goal was do people need pelvic RT adjunctive

What was the study design for GOG 99, 2004?

Answer 2

RCT s/p surgery, NAT or pelvic RT; toxicity, recurrence and OS

Question 3

Who were the HIR in GOG99

Answer 3

Mod to poor diff tumor, LVI and outer 1/3 MI; Age 50+ with 2 of these or 70+ with any risk factor

Question 4

GOG99 results

Answer 4

n=329 (1:1); 12 deviations in RT; HIR saw diff more
Overall: CIR 12% NAT vs 3% RT
Subgroup: HIR 26 vs 6%
RT affect pelvic and vaginal recurrences
No SS in OS (86 vs 92%)