ASTEC RT, 2009 Flashcards
1
Q
What was the study design of ASTEC (RT) + EN.5?
A
Ph 1 - Stage 1-IIa hyst +/- LAD (PA nodes at surgeon discretion)
Ph 2 - HIR RCT to RT or observation
2
Q
ASTEC RT study question?
A
Does post op EBRT in intermediate or high risk of recurrence and death improve RFS or OS?
3
Q
Who was the EN.5 trial?
A
Canadian group, could not recruit enough
4
Q
Inclusion criteria for ASTEC/EN.5
A
Stage 1-IIA, intermediate or high risk; Stage 1A or 1B G3, 1C all; pap serous or clear cell; LN not required
5
Q
Results ASTEC/EN.5?
A
No benefit to post op RT
No impact of outcomes when stratifying by lymphadenectomy
6
Q
Critique of ASTEC/EN.5
A
Only 70% in all arms with full LAD
Staging did not guide therapy
50% in EBRT also with VBT
