pom- bleeding disorders- unfinished

Question 1

3 causes of hemostatic defects

Answer 1

platelet abnormalities
vessel abnormalities
coagulation factor abnormalities

Question 2

virchow’s triad

Answer 2

reduction in blood flow
changes in the blood vessel wall
increased coag of blood

Question 3

what does virchows triad indicate?

Answer 3

possible venous thrombosis

Question 4

four phases of coagulation

Answer 4

vascular phase
platelet phase
coag cascade
fibrinolytic phase

Question 5

three parts of coag cascade

Answer 5

intrinsic
extrinsic
common pathway

Question 6

what phase occurs when you get an injury to the endothelium

Answer 6

vascular phase

Question 7

describe vascular phase

Answer 7

immediate vasoconstriction caused by serotonin, histamine and pg

Question 8

describe the platelet phase

Answer 8

platelets aggregate on the damaged vessel wall, create plug

Question 9

what are 2 further components for aggregation and promotion of clotting?

Answer 9

adp, pf3

Question 10

what are receptors for platelets- 2?

Answer 10

gp11b, gpiiia

Question 11

what else is involved in migration of platelets to the site other than the receptors?

Answer 11

von willebrand factor in endothelium

Question 12

where are clotting factors synth

Answer 12

liver

Question 13

what is the coagulation cascade

Answer 13

converts fibrinogen to fibrin

Question 14

what mediates coag cascade

Answer 14

thrombin

Question 15

what is thrombin made from

Answer 15

prothrombin

Question 16

what mediates change of prothrombin to thrombin

Answer 16

factor X

Question 17

defintion of intrinsic pathway of coag cascade

Answer 17

true cascade, initated by exposure of factor xii to surface agents ( like collagen)

Question 18

define extrinsic pathway

Answer 18

involves factor vii which complexes w calcium and tissue factor

Question 19

where do intrinsic and extrinsic pathways interact? exam

Answer 19

right in the middle of the cascade with factor V and X meeting each other

Question 20

tissue thromboplastin (tpa)

Answer 20

given to pt who had stroke, within 2 hr, to prevent further stroke

Question 21

normal platelet range

Answer 21

150,000-400,000 /uL

Question 22

thrombocytopenia

Answer 22

<50,000/uL

Question 23

spontaneous bleeding

Answer 23

<20,000/uL

Question 24

causes of thrombocytopenia

Answer 24

drug induced, immune thrombocytopenia purpura

Question 25

what causes drug induced thrombocytopenia

Answer 25

marrow toxicity or platelet destruciton

Question 26

what are the most common drugs that suppress megakaryocyte production

Answer 26

etoh and thiazide dieuretic

Question 27

what are the most common drugs to cause platelet destruction

Answer 27

quinidine and quinin

Question 28

what causes peripheral platelet destruction most commonly?

Answer 28

immune system problem

Question 29

when does drug induced thrombo appear?

Answer 29

severlly and sudddenly

Question 30

how do you treat drug induced thrombo?

Answer 30

corticosteroid or give iv platelets

Question 31

2 types of immune thrombocytopenia purpura

Answer 31

acute, chronic

Question 32

definition of immune thrombocytopenia purpura

Answer 32

autoab facil platelet destruction

Question 33

acute itp is mostly a – dz or assoc with –

Answer 33

pediatric, hivd

Question 34

how to treat itp

Answer 34

gcs, iv ig, splenectomy, immunosuppressives

Question 35

how does itp present?

Answer 35

petechiae, purpura, hepaomegaly and splenomegaly

Question 36

chronic itp usually seen in

Answer 36

women- unknown cause

Question 37

is chrnoic more or less severe than acute itp?

Answer 37

less

Question 38

what is chronic itp usually seen w?

Answer 38

underlying dz like lymphoma, sarc, sle

Question 39

what other broad thing can cause thrombocytopenia?

Answer 39

bone marrow failure