polycythaemia Flashcards
what are myeloproliferative disorders
conditions occur due to uncontrolled proliferation of a single type of stem cell. They are considered a type of bone marrow cancer.
proliferation of haematopoietic stem cells causes..
primary myelofibrils
proliferation of erythroid cells causes
polycythaemia vera
proliferation of megakaryocyte causes …
essential thrombocythaemia
myelofibrosis is where the proliferation of the cell line leads to ….
fibrosis of the bone marrow
systemic symptoms of myeloproliferative disorders
Fatigue
Weight loss
Night sweats
Feve
In someone with suspected polycythaemia vera, there are three key signs on examination:
-Conjunctival plethora (excessive redness to the conjunctiva in the eyes)
-A “ruddy” complexion
-Splenomegaly
no bleeding, no infection, and high platelet count
haemolytic issue
myeloproliferative conditions are associated with mutations in what genes…
JAK2
MPL
CALR
FBC findings for polycythaemia vera
raised haemoglobin
185g/l in men
165g/l in women
what tests would you request when platelet is high
ESR
FERRITIN
BLOODFILM
what happens to blood when there is a high platelet coubt
blood becomes viscous
two biggest causes of hepatospenamegaly
infection
liver disease
budchiari
thrombosis in hepatic veins
causing large spleen due to pressure
diseases where a large spleen is common
Rheumatoid arthiritis
Systemic lupus erythematosus
LYMPHOMA
