thrombocytopenia

Question 1

what is thrombocytopenia

Answer 1

a low platelet count

Question 2

Issues that relate to production of platelets

Answer 2

Sepsis
B12 or folic acid deficiency
Liver failure causing reduced thrombopoietin production in the liver
Leukaemia
Myelodysplastic syndrome

Question 3

issues that relate to destruction of platelets

Answer 3

Medications
Alcohol
Immune thrombocytopenic purpura
Thrombotic thrombocytopenic purpura
Heparin-induced thrombocytopenia

Question 4

presentation of thrombocytopenia

Answer 4

nosebleeds
bleeding gums
heavy periods
easy bruising
blood in urine or stools

Question 5

what it ITP

Answer 5

Immune Thrombocytopenic Purpura

Question 6

what occurs in Immune Thrombocytopenic Purpura

Answer 6

ITP is a condition where antibodies are created against platelets. This causes an immune response against platelets, resulting in the destruction of platelets and a low platelet count.

Question 7

management of ITP

Answer 7

-prednisolone
- IV immunoglobulin
-rituximab
-splenectoy

Question 8

what is ttp

Answer 8

Thrombotic Thrombocytopenic Purpura

Question 9

what occurs in ttp

Answer 9

tiny blood clots develop throughout the small vessels of the body using up platelets and causing thrombocytopenia

Question 10

why do blood vlots develop in TTP

Answer 10

• issue with protein ADAMTS13
• normally inactivates von willebrand factor& reduces platelet adhesion