Pneumonia Flashcards

1
Q

What is pneumonia?

A

Pneumonia is simply an infection of the lung tissue.

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2
Q

How does pneumonia present on a CXR?

A

Pneumonia can be seen as consolidation on a chest xray.

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3
Q

What are the three classifications of pneumonia?

A

If the pneumonia developed outside of hospital it is labeled labelled “community acquired pneumonia”.

If it develops more than 48h after hospital admission it is labelled “hospital acquired pneumonia”.

If it develops as a result of aspiration, meaning after inhaling foreign material such as food, then it is labelled “aspiration pneumonia”.

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4
Q

Presentation of pneumonia

A

Shortness of breath
Cough productive of sputum
Fever
Haemoptysis (coughing up blood)
Pleuritic chest pain (sharp chest pain worse on inspiration)
Delirium (acute confusion associated with infection)
Sepsis

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5
Q

What signs can indicate a secondary sepsis to pneumonia|?

A
Tachypnoea (raised respiratory rate)
Tachycardia (raised heart rate)
Hypoxia (low oxygen)
Hypotension (shock)
Fever
Confusion
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6
Q

What are the characteristic chest signs of pneumonia?

A

Bronchial breath sounds. These are harsh breath sounds equally loud on inspiration and expiration. These are caused by consolidation of the lung tissue around the airway.

Focal coarse crackles. These are air passing through sputum in the airways similar to using a straw to blow in to a drink.

Dullness to percussion due to lung tissue collapse and/or consolidation.

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7
Q

What severity assessments are used outside of hospital and inside of the hospital?

A

Out: CRB-65
In: CURB-65

The only difference is that out of hospital you do not count urea.

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8
Q

What does CURB 65 stand for?

A

C – Confusion (new disorientation in person, place or time)
U – Urea > 7
R – Respiratory rate ≥ 30
B – Blood pressure < 90 systolic or ≤ 60 diastolic.
65 – Age ≥ 65

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9
Q

How does the curb score predict mortality?

A

Score 1 = under 5%
Score 3 = 15%
Score 4/5 = over 25%

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10
Q

What should you do based off the scores from the CURB-65 scale?

A

Score 0/1: Consider treatment at home
Score ≥ 2: Consider hospital admission
Score ≥ 3: Consider intensive care assessment

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11
Q

Cause of pneumonia

A
Streptococcus pneumoniae (50%)
Haemophilus influenzae (20%)
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12
Q

What is atypical pneumonia?

A

The definition of atypical pneumonia is pneumonia caused by an organism that cannot be cultured in the normal way or detected using a gram stain.

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13
Q

Medication for atypical pneumonia?

A

They don’t respond to penicillins and can be treated with macrolides (e.g. clarithomycin), fluoroquinolones (e.g. levofloxacin) or tetracyclines (e.g. doxycycline).

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14
Q

Atypical pneumonia - Legionella pneumophila (Legionnaires’ disease).

A

This is typically caused by infected water supplies or air conditioning units. It can cause hyponatraemia (low sodium) by causing an SIADH.

The typical exam patient has recently had a cheap hotel holiday and presents with hyponatraemia.

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15
Q

Atypical pneumonia - mycoplamsa pneumoniae

A

Mycoplasma pneumoniae. This causes a milder pneumonia and can cause a rash called erythema multiforme characterised by varying sized “target lesions” formed by pink rings with pale centres. It can also cause neurological symptoms in young patient in the exams.

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16
Q

Atypical pneumoniae - chlamydophila pneumoniae

A

The presentation might be a school aged child with a mild to moderate chronic pneumonia and wheeze. Be cautious though as this presentation is very common without chlamydophilia pneumoniae infection.

17
Q

Atypical pneumonia - coxiella burnetti aka Q fever

A

This is linked to exposure to animals and their bodily fluids. The MCQ patient is a farmer with a flu like illness.

18
Q

Atypical pneumonia - psittaci

A

This is typically contracted from contact with infected birds. The MCQ patient is a from parrot owner.

19
Q

5 causes of Atypical Pneumonia

A

Legions of Psittaci MCQs

M – mycoplasma pneumoniae
C – chlamydydophila pneumoniae
Qs – Q fever (coxiella burnetii)

20
Q

Who does PCP occur in?

A

Pneumocystis jiroveci (PCP) pneumonia occurs in patients that are immunocompromised. It is particularly important in patients with poorly controlled or new HIV with a low CD4 count.

21
Q

What is an example of fungal pneumonia?

A

Pneumocystis jiroveci (PCP)

22
Q

How does fungal pneumonia (PCP) present itself?

A

It usually presents subtly with a dry cough without sputum, shortness of breath on exertion and night sweats.

23
Q

Treatment for PCP

A

Treatment is with co-trimoxazole (trimethoprim/sulfamethoxazole) known by the brand name “Septrin”.

Patients with low CD4 counts are prescribed prophylactic oral co-trimoxazole to protect against PCP.

24
Q

Investigations

A

Patients in the community with CRB 0 or 1 pneumonia do not necessarily need investigations.

Chest xray
FBC (raised white cells)
U&Es (for urea)
CRP (raised in inflammation and infection)

Patients with moderate or severe cases should also have:

Sputum cultures
Blood cultures
Legionella and pneumococcal urinary antigens (send a urine sample for antigen testing)

25
Q

Why are inflammatory markers important in pneumonia?

A

Inflammatory markers such as white blood cells and CRP are roughly raised in proportion to the severity of the infection. The trend can be helpful in monitoring the progress of the patient towards recovery.

For example, repeating WBC and CRP after 3 days of antibiotics may show a downward trend suggesting the antibiotics are working. CRP commonly shows a delayed response so may be low on first presentation then spike very high a day or two later despite the patient improving on treatment. WBC typically responds faster than CRP and give a more “up to date” picture.

Patients that are immunocompromised may not show an inflammatory response and may not have raised inflammatory markers.

26
Q

Antibiotic treatment for CAP

A

Mild CAP: 5 day course of oral antibiotics (amoxicillin or macrolide)

Moderate to severe CAP: 7-10 day course of dual antibiotics (amoxicillin and macrolide)

27
Q

Possible complications of pneumonia

A
Sepsis
Pleural effusion
Empyema
Lung abscess
Death
28
Q

Treatment for HAP

A

penicillin with beta-lactamase inhibitor (piperacillin with tazobactam)

or

tetracycline (tigecycline)

29
Q
A

Pseudomonas - a gram-negative bacillus