Pleuromutilin Flashcards

1
Q

First systemic agent

A

Lefamulin

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2
Q

ليفامولين لا يستطيع قتل

A

P.aeruginosa
Acinetobacter
Enterobacteriaceae

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3
Q

ميكانزم عمل

A

Bind to 50S subunit

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4
Q

علاقته مع الأكل

A

سيئة لازم ساعة قبل الأكل أو ساعتين بعده

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5
Q

الأعراض الجانبية والحمل

A

1/GIT
2/Infusion site reaction

*لایجب ان يستعمل في الحمل.

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6
Q

اللیفه تعذب الکبد لماذا?

A

لأنه یستقلب من خلاله (CYP3A4)ویجب تعدیل الجرعه في الأمراض الكبدية

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7
Q

95-97 % bound to plasma proteins

A

الليفه تتعلق ببروتينات البلازما

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