Platinum Pre-Release Flashcards
what is the systematic name of cisplatin:
cis-diaminodichloroplatinum
draw the trans isomer of cisplatin
what is the coordination number of cisplatin?
4
what is the oxidation state of platinum in cisplatin?
2+
what is a ligand?
an ion/molecule that can donate a lone pair of electrons to form a dative covalent bond
same as a nucleophile in organic chemistry
what are the bond angles in cisplatin?
cisplatin is square planar
90°
what is the bond angle in an ammonia molecule / NH3?
107°
why can ammonia act as a ligand?
the nitrogen has a lone pair of electrons that can be donated
what is the reaction called when water replaces the chlorine ligands in cisplatin?
ligand substitution
or
ligand exchange
what is the Kc equation for the first reaction?
what is the Kc equation for the second reaction?
why is the end product positively charged?
the negative chlorine ions have been replaced with neutral water molecules
so nothing is balancing out the 2+ charge on the central platinum ion
why is the end product more soluble than cisplatin?
cisplatin has hydrogen bonds from amino groups only
diaquadiaminoplatinum has hydrogen bonds from the amino groups as well as ion-dipole interaction from the water
what is the bond angle in water?
104.5°
what type of bond is formed between the platinum ion from cisplatin and the tertiary amine from guanine?
dative covalent bond
which atom is donating the electrons in the dative covalent bond between Pt and N?
the N:
has a lone pair due to being a tertiary amine
what type of bond is formed between the amino group on cisplatin and the carboxyl on guanine?
hydrogen bond
what are the partial charges in the hydrogen bond between cisplatin and guanine?
N = 𝛿-
H = 𝛿+
O = 𝛿-
