Platelet-Hemostasis approach to patient

Question 1

List the common surface receptors that allow platelet to bind endothelium. (4)

Answer 1

1. GP Ia / IIa binds Collagen
2. GP IIb / IIIa binds Fibrinogen
3. GP Ib alpha binds vWF
4. GP Ic / IIa binds Fibronectin

Question 2

Which receptor(s) enhance the binding between platelet and vWF (after the initial lose binding)? (2)

Answer 2

1. Glycoprotein IIb
2. Glycoprotein IIIa

Question 3

What are the important intracellular substances for platelet activation? (2)

Answer 3

1. Alpha granule
2. Dense granule include ADP

Question 4

Why dense granule is called such?

Answer 4

Dense looking under microscope due to content of calcium

Question 5

Funciton of alpha granule

Answer 5

Figure this out

Question 6

Differ the shape of platelet before and after activation

Answer 6

Before: smooth and flat

After: Sphere –> Increase in volume

Question 7

Glycoprotein IIb / IIIa facilitates binding of platelet to? (2)

Answer 7

1. Fibrinogen
2. vWF

Question 8

Briefly describe steps of platelet formation (4)

Answer 8

1. Adhesion: Platelet binds to collagen/vWF at injury site
2. Activation: Platelet expose receptors IIb / IIIa
3. Aggregration: Platelet from fibrinogen bridge
4. Fibrin formation