deck_3474709 Flashcards
stasis dermatitis
-location: lower leg-etiology: lower extremity edema
seborrheic dermatitis
-location: scalp-etiology: malassezia furfur
atopic dermatitis
-location: flexor surfaces-etiology: filaggrin-associated with asthma and allergic rhinits
psoriasis
-location: extensor surfaces, may include arthritis-may be associated with inc. risk of cardiovascular disease
irritant dermatitis
-etiology: common irritants
allergic contact dermatitis
-etiology: common allergens-delayed hypersensitivity reaction type 4-dx confirmed with patch testing
ABCDEs
A-asymmetryB-border irregularityC-color variationD-diameter >6mmE-evolution
keratoacanthoma
x
Langerhans Cells
skin cell critical to antigen processing and presentation to lymphocytes in epidermis
fibroblast
skin cell responsible for producing collagen
pruritis
itch
darker skin color is due to:
differences in packaging and distribution of melanin
pacinian corpusles
responsible for sensation of fine touch
meissners corpusles
x
eccrine glands
x
apocine glands
-primarily located in axilla
sebaceous glands
exemplify holocrine gland secretion
leukocytoclastic vascultitis
immune complex mediated
Bowen’s Disease
-squamous cell carcinoma in situ-linked to HPV infection
melassezia furfur
-associated with: tinea versicolor and seborrheic dermatitis
hemidesmosome
-attach dermis to epidermis-in basement membrane zone
desomsomes
- cell adhesion between keratinocytes in stratum spinosum
Layers of Epidermis
surface- stratified squamous-stratum corneum-stratum granulosum- fillagrin cross links keratin filaments and is important in barrier functinon of skin-stratum spinosum-stratum basalis- melanocytes (skin color)-1 melanocyte: 10 keratinocytes-1 melanocyte can provide color to ~30 keratinocytes
Layers of Dermis
-papillary -reticular-blood vessels and nerves present
Fitzpatrick Skin Types
I. Never tans, always burns, frecklesII. Tans with difficulty, usually burns, frecklesIII. Average tanning, sometimes burns, frecklesIV. Easily tans, rarely burnsV. Very easy to tan, very rarely burnsVI. Never burns
Melanin Types
-eumelanin- black to brown pigment-pheomelanin- yellow to red-brown pigment
Skin Pigmentation Differences
Light Skin: melanosomes smaller and distributed in clusters above the nucleus in the keratinocyteDark Skin: melanosomes larger and distributed individuallythroughout the cytoplasm of the keratinocyte
Flat Morphologies
-macule (<1 cm)-patch
Raised Smooth Morphology
-papule (<1cm)-plaque-cyst-nodule (1-2cm)
Fluid Filled Morphology
-vessicle (1 cm)-pustule (pus)
eschar
crust
Tzanck Prep
test for herpes
Solar Elastosis
-acquired elastic disorder-indicates tissue from older person in sun exposed site
Pseudoxanthoma Elasticum
-congenital elastic disorder-caused by mutation in MDR gene-“plucked chicken skin”
acquired disease of ground structure
-cosmetic filler agent
Ehlers Danlos Syndrome
-congenital disorder of collagen
scurvy
-acquired disorder of collagen
