Plasma Cell Disorders

Question 1

Asymptomatic (Smoldering) Myeloma

Answer 1

pts meet criteria for MM, but have stable course of disease for months to yearshave 10-30% plasma cells and monoclonal serum proteinDo not have lytic bone lesions, renal insufficiency or hypercalcemiaMay develop over MM over several years

Question 2

Plasma Cell Leukemia

Answer 2

Peripheral blood contains >20% plasma cellsprimary plasma cell leukemia typically occurs in younger ptsHepatosplenomegaly & lymphadenopathy, fewer lytic lesions and lower levels of monoclonal proteinsPOOR PROGNOSIS

Question 3

Solitary Plasmacytoma

Answer 3

clonal proliferation of plasma cells that is cytologically and immunophenotypically identical to those of plasma cell myeloma, but manifest as a localized growth or mass** can be interosseous or extramedullary

Question 4

Solitary Plasmacytoma of Bone

Answer 4

by definition, only one tumor identified by radiologic imagingrare, comprising 5% of plasma cell neoplasmssites: vertebrae, ribs, skull, pelvis, femur, clavicle, scapulapts present with localized bone pain and no M-proteinTreatment consists of radiation therapy1/2 will develop plasma cell myeloma

Question 5

Extramedullary Plasmacytoma

Answer 5

by definition, tumor arises outside of bone marrow80% in the upper respiratory tract (nasal cavity, nasopharynx, sinuses)also found in the GI, bladder, CNS15-20% will have M-proteinTx: radiation therapymay recur, but transition to plasma cell myeloma is uncommon