Myeloproliferative Disorders

Question 1

CMLMutation:Frequency:Consequences:

Answer 1

Mutation: BCR-ABL fusion geneFrequency: 100%Consequences: ABL kinase activation

Question 2

Polycythemia veraMutation:Frequency:Consequences:

Answer 2

Mutation: JAK2 point mutationsFrequency: >95%Consequences: JAK2 kinase activation

Question 3

Essential ThrombocythemiaMutation:Frequency:Consequences:

Answer 3

Mutation: JAK2 point mutationsFrequency: 50-60%Consequences: JAK2 kinase activationMutation: MPL point mutationsFrequency: 5-10%Consequences: MPL kinase activation

Question 4

Primary myelofibrosisMutation:Frequency:Consequences:

Answer 4

Mutation: JAK2 point mutationsFrequency: 50-60%Consequences: JAK2 kinase activationMutation: MPL point mutationsFrequency: 5-10%Consequences: MPL kinase activation

Question 5

Systemic mastrocytosisMutation:Frequency:Consequences:

Answer 5

Mutation: c-KIT mutationsFrequency: >90%Consequences: c-KIT kinase activation