planaria

Question 1

evidence neoblasts are pluripotent

Answer 1

if irradiate host and inject a neoblast from healthy donor then clonal clusters produced

single neoblast could rescue a lethally irradiated host as irradiated worm could survive several weeks

neoblast progeny replaced host cells - asexual cells replace host sexual cells and sexual host becomes asexual animal

Question 2

wound response

Answer 2

phase 1 ) generic response. mitosis of neoblasts injury wide

phase two) detection missing tissue and accumulation of neoblasts at blastema.

neoblasts expressing organ specific progenitor markers accumulate at appropriate sites
specific transcription factors drive tissue specific regeneration