PKIE Flashcards
1
Q
Kinetic isotope effect
A
Information arising from different kinetic of reaction using different isotopes of an element
2
Q
PKIE
A
Rate change observed when isotope is incorporated into bond that’s broken/formed in RDS
3
Q
kH/Kd = 1
A
No KIE
4
Q
Origin of PKIE
A
Vibrational energy is related to reduced mass, it’s harder to break C-D bond than C-H and ROD harder to deprotonate than ROH as its less acidic
5
Q
Value of PKIE
A
3-8
6
Q
KH/KD about 3
A
Partial bond breaking at TS, early stage TS
7
Q
KH/KD about 7
A
Full bond breaking at TS, late stage TS
8
Q
Why is H/D most effective
A
Largest difference in reduced mass
