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ATI: PHARM 2 - (Drug Classes) > Pituitary Drugs > Flashcards

Pituitary Drugs Flashcards

1
Q

Octreotide

Chemical Classification

A

Synthetic Octapeptide

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2
Q

Octreotide

Mechanism of Action

A

A potent growth hormone similar to somatostatin

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3
Q

Ocreotide

Uses

A

Sandostatin: acromegaly, improves symptoms of carcinoid tumors, vasoactive intestinal peptide tumors (VIPomas)
LAR Depot: long-term maintenance of acromegaly, carcinoid tumors, VIPomas

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4
Q

Octreotide

Contraindications

A

Hypersensitivity

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5
Q

Octreotide

Side Effects

A

CNS: Headache, Dizziness, Fatigue, Weakness, depression, anxiety, tremors, SEIZURE, paranoia
CV: Sinus Bradycardia, Conduction Abnormalities, DYSRHYTHMIAS. chest pain, SOB, thrombophlebitis, ischemia, CHF, hypertension, palpitations, QT PROLONGATION, ST- OR T-WAVE CHANGES
ENDO: Hypo/Hyperglycemia, Ketosis, Hypothyroidism, galactorrhea, diabetes insipidus
GI: Diarrhea, Nausea, Abdominal Pain, Vomiting, Flatulence, Distention, Constipation, HEPATITIS, increased LFTs, GI BLEEDING, PANCREATITIS, cholelithiasis, ileus
GU: UTI
HEMA: hematoma of inj site, bruise
INTEG: rash, urticaria, pain; inflammation at inj site
MS: Joint and Muscle Pain

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6
Q

Octreotide

Nursing Considerations

A

ASSESS:

  • Growth hormone antibodies, IGF-1 at 1- to 4-hr intervals for 8-12 hr after dose (ACROMEGALY); 5-HIAA, plasma serotonin; blood glucose, serotonin levels (CARCINOID TUMORS), plasma substance P, plasma vasoactive intestinal peptide (VIP) (VIPoma)
  • Thyroid function tests: T3, T4, T7, TSH to identify hypothyroidism
  • Fecal fat, serum carotene
  • ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
  • CARDIAC STATUS: bradycardia, conduction abnormalities, dysrhythmias; monitor ECG for QT prolongation, low voltage, axis shifts, early repolarization, R/S transition, early wave progression
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7
Q

Somatropin

Functional Classification

A

Pituitary hormone

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8
Q

Somatropin

Chemical Classification

A

Growth Hormone

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9
Q

Somatropin

Mechanism of Action

A

Stimulates growth; somatropin is similar to natural growth hormone; both preparations were developed with the use of recombinant DNA

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10
Q

Somatropin

Uses

A

Pituitary growth hormone deficiency (hypopituitary dwarfism), children with human growth hormone deficiency/growth failure, AIDS wasting syndrome, cachexia, adults with somatropin deficiency syndrome (SDS), short stature in Noonan syndrome, SHOX deficiency, Turner’s syndrome, Prader-Willi syndrome

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11
Q

Somatropin

Contraindications

A

Hypersensitivity to benzyl alcohol, creosol; closed epiphyses, intracranial lesions, acute respiratory failure, Prader-Willi syndrome with obesity, trauma

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12
Q

Somatropin

Side Effects

A

CNS: headache, growth of intracranial tumor, fever, aggressive behavior
ENDO: hyperglycemia, ketosis, hypothyroidism
GI: nausea, vomiting
GU: Hypercalciuria
INTEG: rash, urticaria, pain; inflammation at inj site, hematoma
MS: tissue swelling, joint and muscle pain
SYST: ANTIBODIES TO GROWTH HORMONE

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13
Q

Somatropin

Nursing Considerations

A
  • Signs/symptoms of diabetes
  • Growth hormone antibodies if patient fails to respond to therapy
  • Thyroid function tests: T3,T4,T7, TSH to identify hypothyroidism
  • ALLERGIC REACTION: rash, itching, fever, nausea, wheezing
  • HYPERCALCIURIA: urinary stones; groin, flank pain; nausea, vomiting, urinary frequency, hematuria, chills
  • Growth rate, bone age of child at intervals during treatment
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14
Q

Vasopressin

functional Classification

A

pituitary hormone

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15
Q

Vasopressin

Chemical Classification

A

Lysine, Vasopressin

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16
Q

Vasopressin

Mechanism of Action

A

Promotes the reabsorption of water via action on the renal tubular epithelium; causes vasoconstriction

17
Q

Vasopressin

Uses

A

Diabetes insipidus (nonnephrogenic/nonpsychogenic), abdominal distention postoperatively, bleeding esophageal varices

18
Q

Vasopressin

Contraindications

A

Hypersensitivity, chronic nephritis

19
Q

Vasopressin

Side Effects

A

CNS: drowsiness, headache, lethargy, flushing, vertigo
CV: increased BP, dysrhythmias, CARDIAC ARREST, SHOCK, chest pain, MI
EENT: nasal irritation, congestion, rhinitis
GI: nausea, heartburn, cramps, vomiting, flatus
GU: vulval pain, uterine cramping
MISC: tremor, sweating, vertigo, urticaria, bronchial constriction

20
Q

Vasopressin

Nursing Considerations

A

ASSESS:

  • Pulse, BP when giving product IV or IM
  • I& ratio, weight daily; fluid/electrolyte balance; check for edema in extremities; if water retention is severe, diuretic may be prescribed
  • WATER INTOXICATION: lethargy, behavior changes, disorientation, neuromuscular excitability
  • Small doses may precipitate coronary adverse effects; keep emergency equipment nearby
21
Q

Octreotide

Functional Classification

A

Growth Hormone, antidiarrheal

ATI: PHARM 2 - (Drug Classes) (40 decks)

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