Pituitary

Question 1

Knosp grading - resection/remission rates

Answer 1

1 - 83%/88%
2 - 71%/60%
3A - 85%/67%
3B - 64%/0%
4 - 0%/0%

Question 2

Evaluate Pituitary function after how many Gy radiation?

Answer 2

30 Gy

Question 3

Genetic conditions containing pituitary adenoma

Answer 3

AIP
MEN
Carney complex
McCune Albright
Pituitary tumor/paraganglioma

Question 4

Somatic alterations in sporadic pituitary adenoma

Answer 4

GNAS - GH
USP8 - ACTH

Question 5

How often are pituitary, tumors hereditary

Answer 5

~5%

Question 6

What percentage of FIPA cases have an identified germline mutation? Which one?

Answer 6

10%
AIP

Question 7

Inheritance pattern of AIP

Answer 7

Autosomal dominant with incomplete penetrance

Question 8

Likelihood of AIP mutation, depending on age

Answer 8

< 18 years, up to 20%
3% in unselected

Question 9

Clinical presentation of AIP
Tumor types

Answer 9

GH
GH plus PRL
PRL
rarely silent GH
TSH 1 case

Younger macros (teenagers)
Often invasive
Predisposition to apoplexy
Poor response to first gen somatostatin analogues

Question 10

Average age of onset of AIP-negative FIPA

Answer 10

38

Question 11

Which modern antipsychotic does not increase prolactin

Answer 11

Aripiprazole

Question 12

Which cancers metastasize to Pituitary?

Answer 12

Renal cell
Lung
Breast

Question 13

Appearance of histiocytosis on MRI with respect to contrast enhancement

Answer 13

Enhances

Question 14

Appearance on MRI of met with respect to enhancement

Answer 14

Hypoenhancing