Pituitary

Question 1

Knosp grading - resection/remission rates

Answer 1

1 - 83%/88%
2 - 71%/60%
3A - 85%/67%
3B - 64%/0%
4 - 0%/0%

Question 2

Evaluate Pituitary function after how many Gy radiation?

Answer 2

30 Gy

Question 3

Genetic conditions containing pituitary adenoma

Answer 3

AIP
MEN
Carney complex
McCune Albright
Pituitary tumor/paraganglioma

Question 4

Somatic alterations in sporadic pituitary adenoma

Answer 4

GNAS - GH
USP8 - ACTH

Question 5

How often are pituitary, tumors hereditary

Answer 5

~5%

Question 6

What percentage of FIPA cases have an identified germline mutation? Which one?

Answer 6

10%
AIP

Question 7

Inheritance pattern of AIP

Answer 7

Autosomal dominant with incomplete penetrance

Question 8

Likelihood of AIP mutation, depending on age

Answer 8

< 18 years, up to 20%
3% in unselected

Question 9

Clinical presentation of AIP
Tumor types

Answer 9

GH
GH plus PRL
PRL
rarely silent GH
TSH 1 case

Younger macros (teenagers)
Often invasive
Predisposition to apoplexy
Poor response to first gen somatostatin analogues

Question 10

Average age of onset of AIP-negative FIPA

Answer 10

38

Question 11

Which modern antipsychotic does not increase prolactin

Answer 11

Aripiprazole