Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

D&T test 8 > Picornaviruses > Flashcards

Picornaviruses Flashcards

1
Q

Which Enterovirus(es) cause: Poliomyelitis?

A

Poliovirus, EV-71

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which Enterovirus(es) cause Meningitis/Encephalitis:

A

Coxsackie A&B; Echovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which Enterovirus(es) cause: Myocarditis/Pericarditis

A

Coxsackie B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which Enterovirus(es) cause:Pleurodynia

A

Coxsackie B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which Enterovirus(es) cause:Hand Foot and Mouth dz

A

Coxsackie A, EV-71

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which Enterovirus(es) cause Herpangia:

A

Coxsackie A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which Enterovirus(es) cause Respiratory Infections:

A

EV-68

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which Enterovirus(es) cause Acute Hemorrhagic Conjunctivitis:

A

EV-70, Coxsackie A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which Enterovirus(es) cause Generalized infx of newborn:

A

Echo, Coxsackie B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what immune cells are important in fighting enterovirus infections

A

B cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

at what point in a picornavirus/enterovirus infx are neutralizing antibodies useful?

A

After spread from pharynx to intestinesthey invade the regional LNs. At this point the virus is usually cleared (i.e., the virus establishes minor viremia, but not major viremia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the 4 main outcomes of poliovirus infections?

A

Asymptomatic infection (MC)
Abortive poliomyelitis (fever less than week)
Non-paralytic poliomyelitis (meningitis, no paralysis, full recovery)
Paralytic poliomyelitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

where does poliovirus replicate

A

motor neurons (lytic infection) of the anterior horn

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How to differentiate between poliovirus and Guillane Barre

A

Guillane-Barre has sensory loss)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

3 types of paralytic poliomyelitis

A

Spinal
Bulbar
combined

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How does Spinal poliomyeltis present

A

flaccid paralysis, atrophy, Usually asymmetric in lower limbs, with sensory perception intact (vs Guillane-Barre)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How does bulbar poliomyelitis present?

A

paralysis of the pharyngeal and laryngeal muscles, facial muscles, and/or tongue.

paralysis of diaphragm and intercostal muscles requiring mechanical ventilation.

18
Q

What is Post-Polio Syndrome and how does it present

A

§ Weakness in muscles that were affected and then recovered
§ Can affect muscles unaffected by the initial, acute polio attack
-Occurs many years later, usually (36 years)

19
Q

2 polio vaccines, route of administration, and what type they are

A

Salk - IM shot, killed/inactivated

Sabin- Oral, live attenuated

20
Q

what is one advantage and one drawback of the (OPV) Sabin vaccine?

A
  • Secretion of vaccine virus could spread immunization to unvaccinated.
  • can cause vaccine-associated paralytic poliomyelitis (VAPP).
21
Q

What is only vaccine given in US

A

Salk (IVP)

22
Q

What is the #1 cause of viral meningitis? (genus and 3 species)

A

1 cause = Enteroviruses: Coxsackievirus A and B, echovirus

23
Q

What age group is most affected with viral meningitis

A

young kids

24
Q

What enteroviruses cause encephalitis

A

the same ones that cause meningitis: Coxsackievirus A and B, echovirus

25
Q

What occurs in WBC (composition and # of cells) in enterovirus meningitis?

A

Cell count = 10 to 500

-neutrophils predominate in first 1 to 2 days then shifts to leukocytes

26
Q

What is best method to dx enterovirus meningits?

A

virus in CSF by nucleic acid amplification tests (NAAT) like RT-PCR

27
Q

what pop is at risk of chronic meningoencephalitis caused by enteroviruses?

A

people (children) with B cell deficiencies: X-linked agammaglobulinemia, severe combined immunodeficiency syndrome

28
Q

What is the main enterovirus that causes myocarditis/pericarditis?

A

Coxsackie B

29
Q

How is coxsackie B myocarditis/pericarditis diagnosed? (3 ways)

A
  • Viral RNA present in endomyocardial bx
  • RT-PCR positive serum, stool, throat swab
  • 4 fold increase in antibody titer over several week
30
Q

What is the major sequelae of coxsackie B myocarditis/pericarditis?

A

dilated cardiomyopathy.

31
Q

What viruses causes epidemic pleurodynia? by infecting what cells? outocme?

A

Coxsakievirus B infects skeletal muscle cells (intercostals)

complete recovery usually

32
Q

What 2 viruses cause HFMD

A

Coxsackie A and EV-A71

33
Q

What virus is causing large outbreaks of HFMD in the Asia-Pacific region and the serious complication?

A

EV-A71: Brainstem Encephalitis (rhombencephalitis) predominantly affects gray matter

34
Q

what virus cause herpangina

A

coxsackie A

35
Q

What 2 viruses that cause acute hemorrhagic conjunctivitis

A

EV-70 and Coxsackievirus A

36
Q

2 Sx of acute hemorrhagic conjunctivitis

A

Watery discharge that begins in one eye and progresses to the other eye
Subconjunctival hemorrhage seen in most cases

37
Q

What 2 viruses cause Generalized infection of Newborns?

A

Echovirus, Coxsackie B

38
Q

What are the ○ Two Main manifestations of generalized infection of newborns?

A 
§ Myocarditis (CV-B) CFR 30-50%
Fulminant Hepatitis (Echovirus), CFR >50%
39
Q

What is the name of the virus that caused an outbreak of serious respiratory infections in children in 2014

A

EV-68

40
Q

What serious side effect is associated with the virus that caused serious respiratory infections in children in 2014?

A

acute flaccid paralysis

D&T test 8 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions