Physiology Part 2 Flashcards
Aortic arch transmits via _____ to __________
Vagus nerve, solitary nucleus of medulla
Aortic arch responds to….
Increase in BP
Carotid sinus transmits via _________ to _________
Glossopharyngeal nerve, solitary nucleus of medulla
Carotid Sinus responds to…
Increase and decrease in BP
What is the organ with the largest blood flow (100% of CO)?
Lung
What is the organ with the largest share of systemic CO?
Liver
What is the organ with the highest blood flow per gram of tissue?
Kidney
What is the AV O2 extraction of the heart?
80%
Increased O2 demand in the heart is met by _________ not _____
Increased coronary blood flow, not increased extraction of O2
PCWP is a good approximation of….
Left atrial pressure
In mitral stenosis, PCWP is _____ LV diastolic P
Greater than
How do you measure PCWP?
Swan-Ganz catheter
Factors determining autoregulation in the heart?
Local metabolites (vasodilatory): CO2, Adenosine, NO
Factors determining autoregulation in the brain?
Local metabolites (vasodilatory): CO2 (pH)
Factors determining autoregulation in the kidneys?
Myogenic and tubuloglomerular feedback
Factors determining autoregulation in the lungs?
Hypoxia causes vasoconstriction (unique)
Factors determining autoregulation in the skeletal muscle?
Local metabolites: Lactate, adenosine, K+
Factors determining autoregulation in the skin?
SNS controlled by temperature
What is Pc?
Capillary pressure that pushes fluid out of the capillary
What is Pi?
Interstitial Fluid Pressure that pushes fluid in to the capillary
What is pieC?
Plasma colloid osmotic pressure that pulls fuild into the capillary
What is PieI?
Interstitial fluid colloid osmotic pressure that pulls fluid out of the capillary
What is the equation for net filtration pressure?
Pnet=(Pc-Pi)-(PieC-PieI)
What is Kf?
Filtration constant (capillary permeability)
