Embryology Flashcards
Truncus Arteriosus gives rise to…
Ascending aorta and pulmonary trunk
Bulbus Cordis gives rise to…
Smooth parts (outflow tract) of L and R ventricles
Primitive ventricle gives rise to…
Trabeculated L and R ventricles
Primitive atria gives rise to…
Trabeculated L and R atria
L horn of Sinus Venosus gives rise to…
Coronoary Sinus
R horn of Sinus Venosus gives rise to…
Smooth part of R atrium
R common cardinal vein and R anterior cardinal vein give rise to…
SVC
What is the pathway to the formation of the asc. aorta and pulm. trunk
Neural crest migration–>Truncal and bulbar ridges that spiral and fuse to form the AP septum–>Asc. Aorta and Pulm. Trunk
What is the different pathology that can come from malformation of the Truncus Arteriosis
TGV (failure to spiral)
TOF (skewed AP septum devo)
Persistent TA (partial AP septum development)
What is the first step in IV septum development
Muscular ventricular septum forms and the opening is called the IV foramen
What is the second step in IV septum development
AP septum rotates and fuses with muscular ventricular septum to form membranous IV septum, closing the IV foramen
What is the third step in IV septum development
Endocardial cushion growth separating the atria and ventricles and contributes to separation of atria and also to the membranous portion of the IV septum
What is the pathology that can result from malformation of IV septum
TGA or Persistent TA (improper neural creast migration)
L to R shunt (membranous septal defect)–>Can reverse to R to L due to onset of pulmonary HTN (Eisenmenger’s syndrome)
Step 1 in IA septum devo
-Septum primum grows toward endocardial cusions
Step 2 in IA septum devo
- Froamen Primum disappears
- Perforations in septum primum forms foramen secundum
Step 3 in IA septum devo
- Froamen secundum maintains R to L flow
- Septum secundum begins to grow
Step 4 in IA septum devo
-Septum secundum contains foramen ovale
Step 5 IA septum devo
- Upper part of septum primum degenerates
- Septum secundum enlarges
Step 6 IA septum devo
-Remaining part of septum primum forms the valve of foramen ovale
What fuses to form the atrial septum
-Septum secundum and septum primum
What pathology results from malformation of IA septum
Patent foramen ovale (failure of septum primum and septum secundum to fuse after birth)
Where does fetal erythropoiesis occur?
Young Liver Synthesizes Blood
- Yolk sac (3-10 weeks)
- Liver (6 weeks-birth)
- Spleen (15-30 weeks)
- Bone marrow (22 weeks-adult)
What is the postnatal derivative of the umbilical vein?
Ligamentum teres hepatis
Note: Contained in falciform ligament
What is the postnatal derivative of the Umbilical arteries?
Medial umbilical ligaments
