Physiology of Healing Flashcards
3 phases of healing
inflammatory response
fibroblastic repair
maturation-remodeling
T or F: the body must go through the inflammatory response to heal
T
symptoms of inflammation
swelling, pain, warmth, redness, crepitus, loss of function
what happens during the inflammatory phase? how long is it?
- the injured area is walled off and leukocytes phagocytize foreign debris
- lasts 2-4 (up to 10) days after injury
physiological cause of edema
increased permeability of blood vessels
physiological cause of erythema and warmth
increased blood flow
what are some factors that influence inflammatory phase?
- medical conditions
- meds
- immobilization
- location of injury
- age
- nutrition
- physical agents
acute inflammation
local tissue damage
pain all the time
sub-acute inflammation
pain is actively related
can last 4-6 weeks if not managed
chronic inflammation
the longer pain lasts, the high the chance of pain being referred away from original location
* sign of impaired healing
what happens in the fibroblastic repair (proliferative) phase? how long is it?
- regeneration leads to scar formation and repair of injured tissue
- lasts 4-6 weeks
fibroplasia
the formation of fibrous tissue beginning within the first few hours after injury
clinical signs of fibroplasia
- inflammation signs subside
- if open wound you will be able to see tissue formation
by 6-7 days after injury fibroblasts begin producing _________
collagen
T or F: A persistent inflammatory response can lead to abnormal proliferation
T: due to extended fibroplasia and fibrogenesis (hypertrophic and keloid scars may result)
what happens in maturation-remodeling phase? how long?
- realignment of collagen fibers along lines of tensile force
- ongoing breakdown/ synthesis of collagen
- may require several years to complete
how is scar tissue different than normal tissue
lacks elastin and weaker
scar tissue is initially type ___ collagen in a random pattern and once it matures it is type _______ in an organized pattern
3,1
*no elastin like in normal skin
what are some local factors associated with delayed healing
moisture
pressure
friction
shear
continued injury
inappropriate management
what are some systemic factors associated with delayed healing?
circulation
sensation
inadequate nutrition
age
body habitus
co-morbidities
meds
behavioral risk taking