Physiology/Immunology

Question 1

Calmodulin

Answer 1

Cytoplasmic calcium binding protein; control calcium-ATPase pumps

Question 2

Half life of IgG

Answer 2

23 days

Question 3

Most common HDFN

Answer 3

ABO - due to IgG anti-A,B

Question 4

Calculation for RhIg dosage

Answer 4

Vials of RhIG = %fetal cellsx50 /30 (mls RbcS neutralized). +1 extra vial

Question 5

T- cells produced where? What do they make?

Answer 5

Thymus; cytokines

Question 6

B-cells produced where? What do they make?

Answer 6

Bone marrow; antibodies

Question 7

Papain cleaves (above) hinge region of IgG - leaves which fragments?

Answer 7

2 Fab and 1 Fc fragment

Question 8

Production of antibody is component of this type of immunity/defense mechanism

Answer 8

Adaptive - antibody production

Innate = skin, phagocytes, mucous membranes

Question 9

DIIHA - drug induced immune hemolytic anemia caused by these 3 common drugs

Answer 9

Piperacillin
Cefotetan
Ceftriaxone

Question 10

Drug causing hemolysis by “drug INDEPENDENT”mechanism

Answer 10

fludarabine

Question 11

HLA - alleles to match

Answer 11

HLA-A
HLA-B
HLA-C
HLA-DQB1

Question 12

Plasma exchange - % original plasma remaining

Difference =amount removed

Answer 12

-1 vol = 35%
1.5 vol = 25%
2 vol =12%
2.5 vol = 8%
3 vol = 4%

Question 13

Sickle cell exchange transfusions do the following:

Answer 13

-reduce stroke risk
-reduce organ damage/sickling
-suppress retics from producing more HgbS+ cells
- maintain hgb level 8-9g/dL

Question 14

?? Sickle cell amino acid mutation

Answer 14

Position 6 Valine instead of Glutamic acid

Question 15

Factor deficiency found in Ashkenazi Jewish

Answer 15

Factor XI (11)
Hemophilia C

Up to 8% affected - autosomal inheritance