Physiology - Exam 3, Deck #1 - Skeletal Flashcards
What are Long Bones?
-Have long longitudinal axes and expanded ends; EX: Forearm and thigh bones
What are Short Bones?
- Are somewhat cubelike with their lengths and widths roughly equal;
- EX. Bones of wrists and ankles
What are Flat Bones?
Are platelike structures with broad surfaces
-EX: the ribs, scapulae, and some bones of the skull
What are Irregular Bones?
Have a variety of shapes and are usually connected to several other bones;
-EX: Vertebrae that comprise the backbone and many facial bones
What are Sesamoid or Round Bones?
-Usually small and nodular and are embedded within tendons adjacent to joints, where the tendons are compressed;
EX. Kneecap or patella
What are the part of a Long Bone?
- Epiphysis (distal/ proximal)
- Diaphysis
- Compact bone
- Spongy bone
- Articular cartilage
- Periosteum
- Endosteum
- Medullary cavity
- Trabeculae
- Marrow (red/yellow)
What is the Epiphysis?
- Expanded portion at each end; articulates (or forms a joint) with another bone;
- Articular cartilage covers
- Largely composed of spongy bone, or cancellous bone, with layers of compact bone on their surfaces
What is Articular Cartilage of long bones?
A layer of HYALINE cartilage which coats the outer surface of the articulating portion of the epiphysis
What is Spongy of Cancellous Bone?
Spongy bone consists of many branching plates called TRABECULAE;
-Trabeculae are most highly developed in the regions of the epiphysis that are subjected to compressive fractures
What is the Diaphysis of Long Bones?
The shaft of the bone which is located between the epiphyses;
-Wall is mostly composed of tightly packed tissue called compact bone, or cortical bone; has a continuous matrix with no gaps
What is the Medullary Cavity of Long Bone
Compact bone in the diaphysis of a long bone forms a semirigid tube with a hollow chamber called the MEDULLARY CAVITY that is continuous with the spaces of the spongy bone
What is found in the Medullary Cavity?
- Endosteum – is a thin membrane containing bone-forming cells; lines the medullary cavity
- Marrow is a specialized type of soft connective tissue that fills the cavity
—Red marrow = hemopoietic – forms red blood cells, white blood cells, blood platelets
—Yellow marrow = stores fat and is inactive in blood cell production
What is the Periosteum of long bones?
The tough, vascular COVERING of fibrous tissue over all of the bone EXCEPT for the articular cartilage area of the epiphysis
What are Processes of long bones?
Bony projections that provide sites for attachment of ligaments and tendons
What are Osteocytes?
- Bone Cells;
- Located in tiny, bony chambers called LACUNAE, which form concentric circles around central canals (Haversian canals)
What are Haversian Canals?
Canals around which osteocytes and lacunae encircle
What are Canaliculi?
Small passageway though which Osteocytes transport nutrients and wastes to and from nearby cells by means of cellular processes
What is the main intercellular material in bones?
- The intercellular material of bone tissue is largely COLLAGEN and INORGANIC SALTS;
- Collagen gives bone its strength and resilience, and inorganic salts make it hard and resistant to crushing
How are the osteocytes (cells) of COMPACT Bone arranged?
- The osteocytes and layers of intercellular material are concentrically clustered around a central canal form a cylinder shaped unit called an OSTEON, sometimes called the Haversian system;
- Many of these units cemented together form the substance of compact bone
What is found in the central canals of Compact Bone?
-Each central canal contains blood vessels and nerve fibers surrounded by loose connective tissue which nourishes bone cells associated with the central canal via GAP JUNCTIONS;
-Central canals pervade bone tissue LONGITUDINALLY
Transverse perforating canals (Volkmann’s canals) interconnect them
What are Transverse Perforation Canals (Volkmann’s Canals) of Compact Bone?
Interconnect the central canals found within compact bone
What is the structure of SPONGY BONE?
- Spongy bone is composed of osteocytes and intercellular material, but the bone cells DO NOT AGGREGATE around central canals;
- The cells lie within the trabeculae and get nutrients from substances diffusing into the canaliculi that lead to the surface of these thin bony plates
What are the 2 ways bones form?
- INTRAMEMBRANOUS bones originate within sheetlike layers of connective tissue
- ENDOCHONDRAL bones begin as masses of cartilage that are later replaced by bone tissue
What is involved Intramembranous Ossification?
- Bones originate within sheetlike layers of connective tissues
- Broad, flat bones
- kull bones (except mandible)
- Intramembranous bones
What is involved in Endochondral Ossification?
- Bones begin as hyaline cartilage
- Most bones of the skeleton
- Endochondral bones
What are Intramembranous Bones?
- The broad, flat, bones of the skull;
- During their development (tissues appear at the sites of the future bones (OSTEOGENESIS), membranelike layers of unspecialized or primitive, connective tissue
What are Osteoblasts?
-Bone-forming cells that deposit bony matrix around themselves
Where does Spongy Bone form?
- Spongy bone forms in all directions along blood vessels, within the layer of primitive connective tissue;
- As development continues, the osteoblasts may become completely surrounded by matrix;
- They become secluded in lacunae
What are Osteocytes?
Osteoblasts that have been secluded in the lacunae
Where does the Periosteum come from?
- Cells of the primitive connective tissue that persist OUTSIDE the developing bone give rise to the periosteum;
- Osteocytes on the INSIDE of the periosteum form a layer of COMPACT BONE over the surface of the newly formed spongy bone
What is Intramembranous Ossification?
Process of replacing connective tissue with bone to form an intramembranous bone
What are Endochondral Bones?
- *MOST bones of the skeleton;
- Develop from HYALINE cartilage shaped like the future bone = Endochondral Ossification
What is involved in the process of Endocholdral Ossification?
- Forming Endochondral bones =
1. Hyaline Cartilage tissues break down as PERIOSTEUM develops;
1. Blood vessels and differentiating osteoblasts from the periosteum invade the disintegrating tissue;
3. Osteoblasts form SPONGY BONE in the space occupied by cartilage;
4. Osteoblasts become osteocytes when bony matrix completely surrounds them;
5. Osteoblasts beneath the periosteum deposit COMPACT BONE around spongy bone
What is the Primary Ossification Center?
- Center of the diaphysis of bones where bony tissue replaces the Hyaline Cartilage;
- Bone then develops outward towards the ends;
- Osteoblasts (from periosteum) deposit compact bone around spongy bone
What is the Secondary Ossification Center?
- *Epiphyses (ends) remain growing cartilage until maturity;
- The Secondary Ossification Center appears at the epiphyses as spongy bone forms
What is an Epiphyseal Plate?
- or Metaphysis;
- A band of cartilage that remain between the two ossification centers as spongy bone is deposited in the diaphysis and in the epiphysis
What are the characteristics of Endochondral Ossification?
- Hyaline cartilage model;
- Primary ossification center = center of bone;
- Secondary ossification centers = at the epiphyses (ends);
- Epipyseal plate = between the ossification centers;
- Osteoblasts = make new bone;
- Osteoclasts = breakdown bone
What is the arrangement of the Epiphyseal Plate?
The cartilaginous cells of the epiphyseal plate appear in FOUR layers, each of which may be several cell layers thick
First Layer of the Epiphyseal Plate
- CLOSEST to the end of the epiphysis;
- Composed of resting cells that DO NOT actively participate in growth;
- Anchors the epiphyseal plate to the bony tissue of the epiphysis
Second Layer of the Epiphyseal Plate
Contains rows of many YOUNG cells undergoing MITOSIS
Third Layer of the Epiphyseal Plate
- Rows of OLDER cells which are left behind when new cells appear;
- Enlarge and thicken the epiphyseal plate;
- Invading OSTEOBLASTS, which secrete calcium salts, accumulate in the intercellular matrix adjacent to the oldest cartilaginous cells
- As the matrix CALCIFIES, the cells begin to die
Fourth Layer of the Epiphyseal Plate
Quite THIN and composed of DEAD cells and intercellular matrix
What are Osteoclasts?
- Large multinucleated cells that BREAK DOWN the calcified matrix;
- Originate by the fusion of single-nucleated white blood cells called MONOCYTES
How do Osteoclasts breakdown bone?
- Osteoclasts secrete an ACID that dissolves the inorganic component of the calcified matrix, and their lysosomal enzymes digest the organic component;
- Osteoclasts also PHAGOCYTIZE components of the bony matrix
What happens after Osteoclasts remove the matrix?
After osteoclasts remove the matrix, bone-building OSTEOBLASTS invade the region and deposit bone tissue in place of the calcified cartilage
For how long do “Long Bones” lengthen?
A long bone continues to LENGTHEN while the cartilaginous cells of the epiphyseal plate are ACTIVE;
-Once the ossification centers of the diaphysis and epiphysis meet and the epiphyseal plates OSSIFY, lengthening is no longer possible in that end of the bone
How do bones THICKEN?
- A developing bone thickens as COMPACT bone is deposited on the OUTSIDE, just beneath the periosteum;
- As compact bone forms on the surface, osteoclasts erode other bone tissue on the inside
What is the Medullary Cavity of Long Bones?
- Space within the diaphysis;
- The inner bone tissue of bone is eroded away by OSTEOCLASTS as compact bone develops and thickens on the outside leaving the medullary cavity
What type of bone remains in the CENTER of the bone?
The bone in the central regions of the epiphysis and diaphysis remains SPONGY
What is Articular Cartilage?
The hyaline cartilage on the ends of the epiphyses that persists throughout life
What can occur if a CHILD’s bone is damaged?
- A child’s long bones are still growing if a radiograph shows EPIPHYSEAL PLATES;
- If a plate is damaged as a result of a fracture BEFORE OSSIFICATION, elongation of that bone may prematurely cease, or if growth continues, it may be uneven
How can Epiphyseal Plate damaged be fixed?
An epiphysis is sometimes altered surgically in order to equalize growth of bones that are developing at different rates
What effect can CANCER have on bone tissue?
BONE CANCERS = abnormally active osteoclasts destroy bone tissue;
-PROSTATE CANCER can have the opposite effect than cancer cells stimulating ostoblast activity = Promotes formation of NEW bone on the surface of the bony trabeculae
What maintains homeostasis of bone tissue?
After bones are formed, the actions of osteoclasts and osteoblasts continually remodel them
- Osteoclasts resorb bone tissue;
- Osteoblasts replace the bone
* *3-5% of bone calcium is replaced per year
Osteoblasts vs. Osteoclasts
- Osteoblast activity is HIGHER than osterclast activity until age 35 = more replaced bone
- AFTER 35 osteoclast activity is higher than osteoblast activity for the remainder of life = more bone breakdown
What is Bone Resportion?
action of osteoclasts and parathyroid hormone
What is Bone Deposition?
action of osteoblasts and calcitonin
What is Osteoporosis?
- Decreased bone matrix!!
- Most common of all bone diseases in adults, especially in old age;
- Results from diminished organic bone MATRIX rather than poor bone calcification (which would be osteomalacia and rickets)
- *Due to a PROTEIN deficiency
What cellular activity Osteoporosis?
In osteoporosis, the osteoblastic activity in the bone usually is LESS than normal, and consequently the rate of bone osteoid deposition is depressed.;
-Occasionally, as in hyperparathyroidism, the cause of the diminished bone is excess osteoclastic activity