Physiology: CO2 transport in blood & the haldane effect

Question 1

what are the different ways CO2 is transported in blood (3)

Answer 1

in solution(10%)
as Bicarbonate(60%)
as Carbamino compounds(30%)

Question 2

what law applies to CO2 in solution and how does CO2 solubility compare to O2

Answer 2

Henry’s Law

CO2 20 times more soluble

Question 3

what enzyme is used to form bicarbonate

Answer 3

Carbonic annyhydrase

Question 4

where is bicarbonate formed

Answer 4

in RBCs

Question 5

what are carbamino compounds formed from

Answer 5

CO2 combo with terminal amine groups in blood proteins

Question 6

give an example of a carbamino compound

Answer 6

globin from haemoglobin combines to give carbamino-haemoglobin

Question 7

what is the haldane effect

Answer 7

removing O2 from Hb increases Hb ability to pick up CO2 and CO2 generated H+

Question 8

what effect does the Bohr and Haldane effect working in synchrony have

Answer 8

O2 liberation(Bohr effect) and uptake of CO2 and CO2 generated H+(Haldane effect) at tissues

Question 9

what does the haldane effect do to the CO2-Hb dissociation curve

Answer 9

shifts it to the right

Question 10

explain how CO2 is liberated at the lungs

Answer 10

at lungs Hb pick-up the O2, this weakens the Hb ability to bind CO2 and H+